A Reversibly Porous Supramolecular Peptide Framework.
A Reversibly Porous Supramolecular Peptide Framework.
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DOI：
10.1002/chem.202202368
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发表时间：
2022-11-25
影响因子：
4.3
通讯作者：
Palma, Aniello
中科院分区：
文献类型：
--
作者：
Brightwell, Dominic F.;Truccolo, Giada;Samanta, Kushal;Fenn, Elliott J.;Holder, Simon J.;Shepherd, Helena J.;Hawes, Chris S.;Palma, Aniello
关键词：
使用仿生构建模块组装新型超分子框架的能力处于令人兴奋的研究领域的前沿。在此，我们提出了第一个聚脯氨酸螺旋，可自组装成可逆多孔、结晶、超分子肽框架（SPF）。该框架由短寡脯氨酸组装而成，采用聚脯氨酸 II 构象，由氢键和分散相互作用驱动。这种新颖的系统已经证明了热活化、客体诱导的动态孔隙率和对映选择性客体包含。与该 SPF 相关的自组装原理将被用作蓝图，以便在 SPF 和金属肽框架的合理设计中进一步开发螺旋肽接头。 使用仿生构建模块组装新型超分子框架的能力处于令人兴奋的研究领域的前沿。在此，我们提出了第一个聚脯氨酸螺旋，可自组装成可逆多孔、结晶、超分子肽框架（SPF）。这种新颖的系统已经证明了热活化、客体诱导的动态孔隙率和对映选择性客体包含。
The ability to use bio‐inspired building blocks in the assembly of novel supramolecular frameworks is at the forefront of an exciting research field. Herein, we present the first polyproline helix to self‐assemble into a reversibly porous, crystalline, supramolecular peptide framework (SPF). This framework is assembled from a short oligoproline, adopting the polyproline II conformation, driven by hydrogen‐bonding and dispersion interactions. Thermal activation, guest‐induced dynamic porosity and enantioselective guest inclusion have been demonstrated for this novel system. The principles of the self‐assembly associated with this SPF will be used as a blueprint allowing for the further development of helical peptide linkers in the rational design of SPFs and metal‐peptide frameworks. The ability to use bio‐inspired building‐blocks in the assembly of novel supramolecular frameworks is at the forefront of an exciting research field. Herein, we present the first polyproline helix to self‐assemble into a reversibly porous, crystalline, supramolecular peptide framework (SPF). Thermal activation, guest‐induced dynamic porosity and enantioselective guest inclusion have been demonstrated for this novel system.
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