Mapping of the genes encoding mouse thromboxane A2 receptor and prostaglandin E receptor subtypes EP2 and EP3.
Mapping of the genes encoding mouse thromboxane A2 receptor and prostaglandin E receptor subtypes EP2 and EP3.
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编码小鼠血栓素 A2 受体和前列腺素 E 受体亚型 EP2 和 EP3 的基因图谱。
DOI：
10.1006/geno.1994.1113
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发表时间：
1994
期刊：
影响因子：
4.4
通讯作者：
Seldin,MF
中科院分区：
文献类型：
--
作者：
Taketo,M;Rochelle,JM;Sugimoto,Y;Namba,T;Honda,A;Negishi,M;Ichikawa,A;Narumiya,S;Seldin,MF
血栓素A2(TXA2)和前列腺素E2(PGE2)是由花生四烯酸形成的两种最具代表性的二十烷类化合物。它们通过特定的细胞表面受体产生广泛的生物学效应。我们利用种间回交小鼠的限制性片段长度变异，分别定位了TXA2受体Tbxa2r和PGE2受体亚型EP2、EP3、Ptgerep2和Ptgerep3的遗传位点。Tbxa2r定位于Chr 10，Ptgerep2定位于Chr 15着丝粒区域，Ptgerep3定位于Chr 3远端。根据小鼠和人类染色体的同源性，预测了这些受体可能的人类基因座。
Thromboxane A2(TXA2) and prostaglandin E2(PGE2) are two of the most representative eicosanoids that are formed from arachidonic acid. They produce a broad spectrum of biological effects mediated through specific cell surface receptors. We have mapped genetic loci for TXA2receptor,Tbxa2r, and for PGE2receptor subtypes EP2and EP3,Ptgerep2andPtgerep3, respectively, using restriction fragment length variants in interspecific backcross mice. None of the three loci cosegregated with each other.Tbxa2rmapped to Chr 10,Ptgerep2mapped to the centromeric region of Chr 15, andPtgerep3mapped to the distal end of Chr 3. Possible human loci for these receptors are predicted based on the homology between mouse and human chromosomes.