The emetic activity of centrally administered cisplatin in cats and its antagonism by zacopride
The emetic activity of centrally administered cisplatin in cats and its antagonism by zacopride
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猫中枢给药顺铂的催吐活性及其扎考必利的拮抗作用
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
R. S. Alphin
中科院分区：
文献类型：
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作者：
W. Smith;E. M. Callaham;R. S. Alphin
摘要-顺铂通过静脉内（i. v.）或脑室内（i. c. v.）猫的呕吐途径。当顺铂i. c. v.给药时，至呕吐发作的平均时间显著缩短（4.0 min vs 100.6 min）。扎考必利i. c. v.（0.02 mg）或i. v.（0.1 mg kg−1）完全阻断了由任一途径给予顺铂引起的呕吐。他们的数据显示顺铂具有中枢催吐成分，并且这被扎考必利阻断。
Abstract— Cisplatin administered by either the intravenous (i.v.) or intra‐cerebroventricular (i.c.v.) route produced emesis in cats. The average time to onset of emesis was decreased significantly (4.0 min versus 100.6 min) when cisplatin was administered i.c.v. Zacopride administered either i.c.v. (0.02 mg) or i.v. (0.1 mg kg−1) completely blocked the emesis due to cisplatin given by either route. Their data show that cisplatin possesses a central emetic component and that this is blocked by zacopride.
DOI：
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发表时间：
1984
期刊：
Federation proceedings
影响因子：
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作者：
Pickel,VM;Armstrong,DM
通讯作者：
Armstrong,DM