DIETARY-FAT IN RELATION TO PROGNOSTIC INDICATORS IN BREAST-CANCER
DIETARY-FAT IN RELATION TO PROGNOSTIC INDICATORS IN BREAST-CANCER
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DOI：
10.1093/jnci/80.11.819
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发表时间：
1988-08-03
影响因子：
10.3
通讯作者：
BELANGER, L
中科院分区：
文献类型：
--
作者：
VERREAULT, R;BRISSON, J;BELANGER, L
本文对666例新诊断的浸润性乳腺癌患者的饮食，尤其是脂肪摄入与乳腺癌预后指标的关系进行了研究。在诊断前一年的饮食是通过访谈来评估的，使用食物频率调查问卷，包括114种食物的摄入量。预后指标包括诊断时腋窝病变、雌激素受体状态和原发肿瘤的组织学特征，如核分级、组织学分级、小管形成、有丝分裂活性和肿瘤细胞的核大小。在校正总能量摄入、年龄、体重和诊断时肿瘤大小后，饱和脂肪摄入的增加与绝经后患者诊断时淋巴结受累的频率增加有关。相反，多不饱和脂肪摄入量的增加与诊断时淋巴结阳性患者百分比的减少有关。在绝经前和绝经后患者中均观察到这种关系。膳食脂肪与肿瘤雌激素受体状态无关。没有发现饮食习惯和原发肿瘤的组织学特征之间的联系。这些数据表明，在乳腺癌的临床前阶段，膳食脂肪可能对乳腺癌的生长或扩散有影响，而且这种影响可能因所考虑的脂肪类型而异。
The relation of diet, especially fat intake, to recognized prognostic indicators for breast cancer was investigated in 666 women with a newly diagnosed infiltrating breast carcinoma. Diet during the year preceding diagnosis was assessed by interview using a food frequency questionnaire covering the intake of 114 food items. Prognostic indicators included axillary nmode involvement at diagnosis, estrogen receptor status, and selected histologic features of the primary tumor such as nuclear grade, histologic grade, tubule formation, mitotic activity, and nuclear size of tumor cells. After adjustment for total energy intake, age, body weight, and tumor size at diagnosis, an increase in saturated fat intake was related to an increased frequency of node involvement at diagnosis among postmenopausal patients. In contrast, an elevation in polyunsaturated fat intake was related to a reduction of the percentage of patients with positive nodes at diagnosis. This relation was observed among both premenopausal and postmenopausal patients. Dietary fat was not related to the estrogen receptor status of tumors. No association was found between dietary habits and histologic features of the primary tumor. These data suggest that dietary fat may have an effect on the growth or spread of breast cancer during the preclinical phase of the disease and that this effect may vary according to the type of fat considered.