Fetal adaptation to stress - Part I: acceleration of fetal maturation and earlier birth triggered by placental insufficiency in humans
Fetal adaptation to stress - Part I: acceleration of fetal maturation and earlier birth triggered by placental insufficiency in humans
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DOI：
10.1016/j.earlhumdev.2004.03.002
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发表时间：
2004-06-01
影响因子：
2.5
通讯作者：
Piazza, PV
中科院分区：
文献类型：
--
作者：
Amiel-Tison, C;Cabrol, D;Piazza, PV
本综述试图通过多学科方法对胎儿应激引发的生物学变化提供综合观点。某些高危妊娠中大脑和肺成熟加速的现象首次在临床上得到描述，并得到生化、电生理学和实验数据的证实。此外，新的实验结果表明，由胎儿营养状况集中介导的胎儿时钟可以决定分娩时间。然而，一些人仍然对这些知识体系对于发达国家产科管理的有用性持怀疑态度。正如第二部分所阐述的那样，后来从各种来源重新引起了对这种宫内应激适应的兴趣。 (C) 2004 Elsevier Ireland Ltd. 保留所有权利。
This review is an attempt to provide an integrative view for the biological changes triggered by fetal stress through a multidisciplinary approach. Acceleration of brain and lung maturation in certain risk pregnancies was first described clinically and confirmed by biochemical, electrophysiological and experimental data. Moreover, new experimental findings suggest that a fetal clock centrally mediated by fetal nutritional status could determine timing of parturition. However, some skepticism persisted about the usefulness of this body of knowledge for obstetrical management in developed countries. The interest concerning this adaptation to intrauterine stress was later renewed from various sources, as developed in Part II. (C) 2004 Elsevier Ireland Ltd. All rights reserved.