Growth and remodelling for profound circular wounds in skin.
Growth and remodelling for profound circular wounds in skin.
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DOI：
10.1007/s10237-014-0609-1
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发表时间：
2015-04
影响因子：
3.5
通讯作者：
Ben Amar, Martine
中科院分区：
文献类型：
--
作者：
Wu, Min;Ben Amar, Martine
Wound healing studies both in vitro and in vivo have received a lot of attention recently. In vivo wound healing is a multi-step process involving physiological factors such as fibrinogen forming the clot, the infiltrated inflammatory cells, the recruited fibroblasts and the differentiated myofibroblasts as well as deposited collagens. All these actors play their roles at different times, aided by a cascade of morphogenetic agents and the result for the repair is approximatively successful but the imperfection is remained for large scars with fibrosis. Here, we want to study wound healing from the viewpoint of skin biomechanics, integrating the particular layered geometry of the skin, and the role of the neighbouring wound epidermis. After 2 days post-injury, it migrates towards the wound centre to cover the hole, the migration being coupled to proliferation at the wound border. Such a process is dominated by the skin properties which varies with ages, locations, pathologies, radiations, etc. It is also controlled by passive (actin, collagen) and active (myo-fibroblasts) fibres. We explore a growth model in finite elasticity of a bilayer surrounding a circular wound, only the interior one being proliferative and contractile. We discuss the occurrence of an irregular wound geometry generated by stresses and show quantitatively that it results from the combined effects of the stiffness, the size of the wound, eventually weakened by actin cables. Comparison of our findings is made with known observations or experiments in vivo.
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影响因子：
2
作者：
Filas BA;Oltean A;Majidi S;Bayly PV;Beebe DC;Taber LA
通讯作者：
Taber LA
DOI：
10.1073/pnas.1217391110
发表时间：
2013-06-25
影响因子：
11.1
作者：
Ben Amar, Martine;Jia, Fei
通讯作者：
Jia, Fei
影响因子：
2.4
作者：
Ciarletta, Pasquale;Ben Amar, Martine
通讯作者：
Ben Amar, Martine
影响因子：
2.9
作者：
Greaves, Nicholas S.;Iqbal, Syed A.;Bayat, Ardeshir
通讯作者：
Bayat, Ardeshir
DOI：
10.1209/0295-5075/2/4/008
发表时间：
1986-08-15
期刊：
EUROPHYSICS LETTERS
影响因子：
--
作者：
BENAMAR, M;POMEAU, Y
通讯作者：
POMEAU, Y