Dynamic chest radiography: clinical validation of ventilation and perfusion metrics derived from changes in radiographic lung density compared to nuclear medicine imaging
Dynamic chest radiography: clinical validation of ventilation and perfusion metrics derived from changes in radiographic lung density compared to nuclear medicine imaging
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DOI：
10.21037/qims-20-1217
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发表时间：
2021-09-01
影响因子：
2.8
通讯作者：
Kasahara, Kazuo
中科院分区：
文献类型：
--
作者：
Tanaka, Rie;Matsumoto, Isao;Kasahara, Kazuo
背景：动态胸片（DCR）是一种使用动态平板探测器（FPD）进行非对比增强的肺功能成像。本研究旨在评估由DCR上肺密度变化得出的通气和灌注指标与核医学成像得出的指标的临床意义。方法：采用动态FPD成像系统，对42例肺癌患者呼吸过程中的DCR图像进行连续采集。对于每个细分的肺区域，计算呼吸和心功能导致的平均像素值（Delta(max)）即肺密度的最大变化，并分别计算通气和灌注时Amax相对于所有肺区域总数的百分比（Delta(max)%）。通过Spearman相关系数(r)和Dice相似系数（DSC），将Delta(max)%与细分肺区域通气和灌注扫描时放射性物质如Tc-99m气体和Tc-99m宏观聚集白蛋白（放射性物质%）的积累进行比较。为了便于视觉评价，将Delta(max)%可视化为颜色缩放，其中较大的Delta（max）值表示较高的颜色强度。结果：我们发现在通气和灌注扫描中Delta(max)%与放射性药物%之间存在中度相关性，灌注指标(r=0.57， P
Background: Dynamic chest radiography (DCR) is a type of non-contrast-enhanced functional lung imaging with a dynamic flat-panel detector (FPD). This study aimed to assess the clinical significance of ventilation and perfusion metrics derived from changes in radiographic lung density on DCR in comparison to nuclear medicine imaging-derived metrics.Methods: DCR images of 42 lung cancer patients were sequentially obtained during respiration using a dynamic FPD imaging system. For each subdivided lung region, the maximum change in the averaged pixel value (Delta(max)), i.e., lung density, due to respiration and cardiac function was calculated, and the percentage of Amax relative to the total of all lung regions (Delta(max)%) was computed for ventilation and perfusion, respectively. The Delta(max)% was compared to the accumulation of radioactive agents such as Tc-99m gas and Tc-99m macro aggregated albumin (radioactive agents%) on ventilation and perfusion scans in the subdivided lung regions, by Spearman's correlation coefficient (r) and the Dice similarity coefficients (DSC). To facilitate visual evaluation, Delta(max)% was visualized as a color scaling, where larger Delta(max) values were indicated by higher color intensities.Results: We found a moderate correlation between Delta(max)% and radioactive agents% on ventilation and perfusion scans, with perfusion metrics (r=0.57, P