Cardiovascular Actions and Therapeutic Potential of Tetramethylpyrazine (Active Component Isolated from Rhizoma Chuanxiong): Roles and Mechanisms.
Cardiovascular Actions and Therapeutic Potential of Tetramethylpyrazine (Active Component Isolated from Rhizoma Chuanxiong): Roles and Mechanisms.
复制标题
四甲基吡嗪（川芎活性成分）的心血管作用和治疗潜力：作用和机制
DOI：
10.1155/2016/2430329
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发表时间：
2016
影响因子：
--
通讯作者：
Shi D
中科院分区：
文献类型：
--
作者：
Guo M;Liu Y;Shi D
川芎是从中草药川芎中分离得到的一种药理活性成分，在中国和东南亚国家用于防治心血管疾病已有近50年的历史。TMP对心血管系统的药理作用已引起人们的极大兴趣。新出现的实验研究和临床试验表明，TMP既可以预防动脉粥样硬化，也可以预防缺血再灌注损伤。TMP的心脏保护作用主要与其抗氧化、抗炎或钙稳态作用有关。本文综述了TMP在心血管系统中的作用和作用机制，为TMP的临床应用提供了一个新的视角。
Tetramethylpyrazine (TMP), a pharmacologically active component isolated from the rhizome of the Chinese herb Rhizoma Chuanxiong (Chuanxiong), has been clinically used in China and Southeast Asian countries for the prevention and treatment of cardiovascular diseases (CVDs) for about fifty years. The pharmacological effects of TMP on the cardiovascular system have attracted great interest. Emerging experimental studies and clinical trials have demonstrated that TMP prevents atherosclerosis as well as ischemia-reperfusion injury. The cardioprotective effects of TMP are mainly related to its antioxidant, anti-inflammatory, or calcium-homeostasis effects. This review focuses on the roles and mechanisms of action of TMP in the cardiovascular system and provides a novel perspective on TMP's clinical use.