Hypoxia Stabilizes Microtubule Networks and Decreases Tumor Cell Chemosensitivity to Anticancer Drugs Through Egr-1
Hypoxia Stabilizes Microtubule Networks and Decreases Tumor Cell Chemosensitivity to Anticancer Drugs Through Egr-1
复制标题
缺氧通过 Egr-1 稳定微管网络并降低肿瘤细胞对抗癌药物的化学敏感性
DOI：
10.1002/ar.21086
复制
发表时间：
2010-03-01
影响因子：
2
通讯作者：
Li, Chao-Jun
中科院分区：
文献类型：
--
作者：
Peng, Wan-Xin;Pan, Fei-Yan;Li, Chao-Jun
The hypoxic environment of solid tumor causes the tumor cells survive and which could protect them from death by facilitating resistance to therapy. Here, we provide evidence that hypoxia can increase tumor cell viability and proliferation through an Egr-1-dependant pathway. Hypoxia protected the microtubules from disassembly, and Egr-1 was colocalized with microtubules in different cell cycle stages. Knockdown of Egr-1 with its siRNA overcame the protection effect of hypoxia and increased the sensitivity of tumor cells to vinblastine under hypoxic conditions. Our results suggest a novel approach for increasing the sensitivity of tumor cells to chemotherapeutics that target microtubule assembly. Anat Rec, 293:414-420, 2010. (C) 2010 Wiley-Liss, Inc.
