Development of a new vaccine for the prevention of Lassa fever.
Development of a new vaccine for the prevention of Lassa fever.
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DOI：
10.1371/journal.pmed.0020183
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发表时间：
2005-06
期刊：
影响因子：
15.8
通讯作者：
Feldmann H
中科院分区：
文献类型：
--
作者：
Geisbert TW;Jones S;Fritz EA;Shurtleff AC;Geisbert JB;Liebscher R;Grolla A;Ströher U;Fernando L;Daddario KM;Guttieri MC;Mothé BR;Larsen T;Hensley LE;Jahrling PB;Feldmann H
Recent importation of Lassa fever into Germany, the Netherlands, the United Kingdom, and the United States by travelers on commercial airlines from Africa underscores the public health challenge of emerging viruses. Currently, there are no licensed vaccines for Lassa fever, and no experimental vaccine has completely protected nonhuman primates against a lethal challenge. We developed a replication-competent vaccine against Lassa virus based on attenuated recombinant vesicular stomatitis virus vectors expressing the Lassa viral glycoprotein. A single intramuscular vaccination of the Lassa vaccine elicited a protective immune response in nonhuman primates against a lethal Lassa virus challenge. Vaccine shedding was not detected in the monkeys, and none of the animals developed fever or other symptoms of illness associated with vaccination. The Lassa vaccine induced strong humoral and cellular immune responses in the four vaccinated and challenged monkeys. Despite a transient Lassa viremia in vaccinated animals 7 d after challenge, the vaccinated animals showed no evidence of clinical disease. In contrast, the two control animals developed severe symptoms including rashes, facial edema, and elevated liver enzymes, and ultimately succumbed to the Lassa infection. Our data suggest that the Lassa vaccine candidate based on recombinant vesicular stomatitis virus is safe and highly efficacious in a relevant animal model that faithfully reproduces human disease. A replication-competent vaccine based on attenuated recombinant vesicular stomatitis virus vector protects non- human primates.
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影响因子：
12.7
作者：
MCCORMICK, JB;MITCHELL, SW;FISHERHOCH, SP
通讯作者：
FISHERHOCH, SP
影响因子：
158.5
作者：
MCCORMICK, JB;KING, IJ;BELMONTWILLIAMS, R
通讯作者：
BELMONTWILLIAMS, R
DOI：
10.1073/pnas.221447598
发表时间：
2001-10-23
影响因子：
11.1
作者：
Lenz, O;ter Meulen, J;Garten, W
通讯作者：
Garten, W
影响因子：
--
作者：
FISHERHOCH, SP;TOMORI, O;MCCORMICK, JB
通讯作者：
MCCORMICK, JB
影响因子：
5.4
作者：
Publicover, J;Ramsburg, E;Rose, JK
通讯作者：
Rose, JK