BDNF Val66 Met polymorphism significantly affects d′ in verbal recognition memory at short and long delays
BDNF Val66 Met polymorphism significantly affects d′ in verbal recognition memory at short and long delays
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DOI：
10.1016/j.biopsycho.2007.08.009
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发表时间：
2008-01-01
影响因子：
2.6
通讯作者：
Weinberger, Daniel R.
中科院分区：
文献类型：
--
作者：
Goldberg, Terry E.;Iudicello, Jennifer;Weinberger, Daniel R.
脑源性神经营养因子（BDNF）基因的val66met位点的一个功能性多态性对该蛋白质的前体形式在细胞内运输以及依赖活性（而非组成性）的分泌具有显著影响。这些差异被认为是人类中与该多态性相关的一些研究结果的基础，包括神经元活力的标志物、内侧颞叶区域的血氧水平依赖（BOLD）激活以及一些行为方面。然而，关于BDNF在行为层面上对各种记忆子过程的影响，仍存在许多重要问题。在这项研究中，我们在一个言语再认记忆范式中检验了val/met多态性的影响，该范式涉及对编码深度的操纵以及回忆的不同延迟，并对先前呈现的目标词的命中情况和对干扰项的正确拒绝进行分析。24名val纯合子个体和24名met携带者个体构成了样本。所有个体均为健康对照。两组之间的智商相当。在研究的编码阶段，通过判断单词是有生命的还是无生命的（“深度”编码），或者它们是否包含字母“A”（浅层编码）来呈现和编码单词。在此阶段之后，立即、半小时后以及24小时后对再认进行测试。BDNF基因型对命中情况和辨别力（d'）有显著影响，至少解释了10%的方差，但对正确拒绝情况或β值没有影响。BDNF与编码水平没有相互作用，与延迟也没有相互作用。总之，BDNF基因型在再认记忆范式中影响“命中情况”，这些发现与BDNF在被认为涉及内侧颞叶的记忆子过程中起重要作用的一般观点是一致的。（C）2007年由爱思唯尔出版公司出版。
A functional polymorphism at the val66met locus in the BDNF gene has significant effects on the pro-form of the protein in intracellular trafficking and activity-dependent, but not constitutive, secretion. These differences are thought to underlie several findings in humans related to this polymorphism, including markers of neuronal viability, BOLD activation in medial temporal Job regions, and some aspects of behavior.However, many important questions remain about the impact of BDNF on various mnemonic subprocesses at the behavioral level. In this study, we examined the impact of the val/met polymorphism in a verbal recognition memory paradigm involving manipulation of depth of encoding and differential delays for recall and analyses of hits for previously presented target words and correct rejections of foils. Twenty-four human val homozygous individuals and 24 met carrier individuals comprised the sample. All were healthy controls. IQ between the groups was equivalent. In the encoding phase of the study, words were presented and encoded either by a decision as to whether they were living or nonliving ("deep") or if they contained the letter "A" (shallow). After this phase, recognition was tested immediately, half an hour, and 24 It later. BDNF genotype had significant effects on hits and discriminability (d'), accounting for at least 10% of the variance, but not on correct rejections or beta. BDNF did not interact with level of encoding, nor did it interact with delay. In sum, BDNF genotypes impacted "hits" in a recognition memory paradigm, findings consistent with the general notion that BDNF plays a prominent role in memory subprocesses thought to engage the medial temporal lobe. (C) 2007 Published by Elsevier B.V.