Epidemiology of pheochromocytoma and paraganglioma: population-based cohort study
Epidemiology of pheochromocytoma and paraganglioma: population-based cohort study
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DOI：
10.1530/eje-20-0628
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发表时间：
2021-01-01
影响因子：
5.8
通讯作者：
Kline, Gregory A.
中科院分区：
文献类型：
--
作者：
Leung, Alexander A.;Pasieka, Janice L.;Kline, Gregory A.
目的：尽管嗜铬细胞瘤和副神经节瘤的发病率和死亡率很高，但对它们的流行病学却知之甚少。主要目的是确定不同种族人群中嗜铬细胞瘤和副神经节瘤的发病率。第二个目标是开发和验证算法的情况下，使用实验室和管理data.Design检测：人口为基础的队列研究在加拿大阿尔伯塔，从2012年至2019年。方法：嗜铬细胞瘤或副神经节瘤患者被确定使用链接的管理数据库和临床记录。计算每10万人的年发病率，并根据年龄和性别分层。算法，以确定嗜铬细胞瘤和副神经节瘤，实验室和管理数据的基础上，evaluated.Results：共239例嗜铬细胞瘤或副神经节瘤（集体与251肿瘤）被确定从人口的5 196 368人在一个为期7年。嗜铬细胞瘤或副神经节瘤的总发病率为0.66例/10万人/年。嗜铬细胞瘤和副神经节瘤的发病率随着年龄的增长而增加，在60-79岁的人群中发病率最高（男性和女性分别为每年每10万人8.85例和14.68例）。基于实验室数据的算法嗜铬细胞瘤和副神经节瘤的发病率（偏嗜铬细胞瘤> 2倍或正常偏嗜铬细胞瘤> 3倍）与其真实发病率非常接近，估计发病率为0.54例/10万人/年。在加拿大西部的一个研究人群中，嗜铬细胞瘤和副神经节瘤的发病率出乎意料地高于其他研究报道的发病率。世界上的一些地区。
Objective: Despite the significant morbidity and mortality associated with pheochromocytoma and paraganglioma, little is known about their epidemiology. The primary objective was to determine the incidence of pheochromocytoma and paraganglioma in an ethnically diverse population. A secondary objective was to develop and validate algorithms for case detection using laboratory and administrative data.Design: Population-based cohort study in Alberta, Canada from 2012 to 2019.Methods: Patients with pheochromocytoma or paraganglioma were identified using linked administrative databases and clinical records. Annual incidence rates per 100 000 people were calculated and stratified according to age and sex. Algorithms to identify pheochromocytoma and paraganglioma, based on laboratory and administrative data, were evaluated.Results: A total of 239 patients with pheochromocytoma or paraganglioma (collectively with 251 tumors) were identified from a population of 5 196 368 people over a period of 7 years. The overall incidence of pheochromocytoma or paraganglioma was 0.66 cases per 100 000 people per year. The frequency of pheochromocytoma and paraganglioma increased with age and was highest in individuals aged 60-79 years (8.85 and 14.68 cases per 100 000 people per year for males and females, respectively). An algorithm based on laboratory data (metanephrine >two-fold or normetanephrine >three-fold higher than the upper limit of normal) closely approximated the true frequency of pheochromocytoma and paraganglioma with an estimated incidence of 0.54 cases per 100 000 people per year.Conslusion: The incidence of pheochromocytoma and paraganglioma in an unselected population of western Canada was unexpectedly higher than rates reported from other areas of the world.