Antinociceptive action of intrathecally administered IGF-I and the expression of its receptor in rat spinal cord
Antinociceptive action of intrathecally administered IGF-I and the expression of its receptor in rat spinal cord
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DOI：
10.1016/0006-8993(96)00747-0
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发表时间：
1996-10-21
期刊：
影响因子：
2.9
通讯作者：
Pilcher, CWT
中科院分区：
文献类型：
--
作者：
Bitar, MS;AlBustan, M;Pilcher, CWT
胰岛素样生长因子I （IGF-I）及其受体的mRNA转录本在脊髓腰椎区表达。因此，我们研究了igf - 1在伤害性传递中的作用。鞘内注射igf -1 （200-1000 ng）产生剂量依赖性的伤害阈值升高，如甩尾/戒断潜伏期所示。相比之下，同等剂量的胰岛素没有显著的效果。时间-反应曲线（15-75 min）显示，IGF-I的抗伤害感受作用在30 min达到峰值。我们的数据提供了脊髓内igf - 1系统可能作为新型镇痛药靶点的证据。
mRNA transcripts for insulin-like growth factor I (IGF-I) and its receptor are expressed in the lumbar region of the spinal cord. Accordingly, we examined the involvement of IGF-I in nociceptive transmission. An intrathecal injection of IGF-I (200-1000 ng) produced a dose-dependent elevation in nociceptive threshold as indicated by tail flick/withdrawal latency. In contrast, comparable doses of insulin had no significant effect. The time-response curve (15-75 min) revealed that the peak for IGF-I's antinociceptive effect is attained at 30 min. Our data provide evidence that the IGF-I system within the spinal cord may serve as a target for novel analgesics.