The influence of foetal haemoglobin on the frequency of vaso-occlusive crisis in sickle cell anaemia patients.
The influence of foetal haemoglobin on the frequency of vaso-occlusive crisis in sickle cell anaemia patients.
复制标题
胎儿血红蛋白对镰状细胞性贫血患者血管闭塞危象频率的影响。
DOI：
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复制
发表时间：
2005
影响因子：
1.1
通讯作者：
OA Awodu
中科院分区：
文献类型：
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作者：
M. Enosolease;OA Ejele;OA Awodu
目的
一些生物和环境因素被认为是镰状细胞贫血患者发病模式的原因。胎儿血红蛋白被认为是降低这些患者发病率的生物学因素之一。我们研究了胎儿血红蛋白水平和血管闭塞危象（VOC）之间的关系，作为这类患者发病率模式的衡量标准。
结果
平均胎儿血红蛋白水平为6.4 ± 0.40%（SEM）。血管闭塞危象在胎儿血红蛋白水平较低时更常见，特别是低于12%时（P=0.01）。胎儿血红蛋白与血管闭塞危象呈负相关（r=0.561）。这些变量在线性回归中也相关，均显示出统计学显著性（p=0.001）。
结论
我们的结论是，较高水平的胎儿血红蛋白积极影响镰状细胞贫血患者血管闭塞性危象的发生。
OBJECTIVE
Several biological and environmental factors are presumed to account for the morbidity pattern in patients with sickle cell anaemia. Foetal haemoglobin is one of the biological factors thought to decrease morbidity in these patients. We studied the relationship between the foetal haemoglobin levels and vaso-occlusive crisis (VOC) as a measure of the morbidity pattern in this category of patients.
RESULTS
The mean foetal haemoglobin level was 6.4+0.40% (SEM). Vaso-occlusive crisis was more common at lower levels of foetal haemoglobin particularly when lower than 12% (P=0.01). There was a negative correlation between foetal haemoglobin and vaso-occlusive crisis (r=0.561). These variables were also associated in linear regression and both showed statistical significance (p=0.001).
CONCLUSION
We conclude that higher levels of foetal haemoglobin positively influence the occurrence of vaso-occlusive crisis in sickle cell anaemia patients.