RELATIONSHIP BETWEEN HYPERTENSION, HYPERTROPHY, AND OPENING ANGLE OF ZERO-STRESS STATE OF ARTERIES FOLLOWING AORTIC CONSTRICTION
RELATIONSHIP BETWEEN HYPERTENSION, HYPERTROPHY, AND OPENING ANGLE OF ZERO-STRESS STATE OF ARTERIES FOLLOWING AORTIC CONSTRICTION
复制标题
DOI：
10.1115/1.3168386
复制
发表时间：
1989-11-01
影响因子：
1.7
通讯作者：
FUNG, YC
中科院分区：
文献类型：
--
作者：
LIU, SQ;FUNG, YC
检查器官在零应力状态下发生的变化提供了一种研究由于物理应力变化导致的器官中细胞生长的方法。主动脉的零应力状态不是一根管子。它是一个扇形，其张开角度随主动脉上的位置而变化，并随细胞重塑而变化。血管重塑可以通过用金属夹（主动脉束带）对腹主动脉施加收缩来诱导，这导致血压升高、主动脉壁肥大和张开角的大变化。本文报告了主动脉缩窄后大鼠主动脉的张开角与血管壁厚度和血压变化的关系。主动脉结扎后，张开角每天都在变化。上半身血管的血压升高，而下半身血管的血压先降低，然后升高到一个渐近值。血管壁厚度与血压大致成比例增加。血管直径也会发生变化。但最引人注目的是零应力状态的变化过程。通常，血管壁厚度达到渐近肥大50%的时间约为3-5天。血压的相应时间约为7天。而零应力状态下的张开角则先迅速增大，在2 ~ 4天左右达到峰值，然后逐渐减小，直至渐近线。时间常数的确切值取决于主动脉树沿着的位置。通常，残余应变的变化过程与血压和血管壁厚度的变化过程非常不同。
Examination of changes occurring in the zero-stress state of an organ provides a way to study cellular growth in the organ due to change of physical stresses. The zero-stress state of the aorta is not a tube. It is a sector with an opening angle that varies with the location on the aorta and changes with cellular remodeling. Blood vessel remodeling can be induced by imposing a constriction on the abdominal aorta by a metal clip (aortic banding), which causes an increase of blood pressure, hypertrophy of the aortic wall, and large change of opening angle. The correlation of the opening angle with the blood vessel wall thickness and blood pressure changes in rat's aorta due to aortic banding is presented in this report. The opening angle changes daily following the aortic banding. Blood pressure rises in vessels of the upper body, but that in the lower body decreases at first and then rises to an asymptotic value. Blood vessel wall thickness increases in rough proportion to blood pressure. Vessel diameter changes also. But the most dramatic is the course of change of the zero-stress state. Typically, the time to reach 50 percent of asymptotic hypertrophy of blood vessel wall thickness is about 3-5 days. The corresponding time for blood pressure is about 7 days. The opening angle of the zero-stress state, however, increases rapidly at first, reaches a peak in about 2 to 4 days, then decreases gradually to a reduced asymptote. The exact values of the time constants depend on the location along the aortic tree. In general, the course of change of residual strain is very different from those of the blood pressure and the blood vessel wall thickness.