REM sleep-active MCH neurons are involved in forgetting hippocampus-dependent memories
REM sleep-active MCH neurons are involved in forgetting hippocampus-dependent memories
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DOI：
10.1126/science.aax9238
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发表时间：
2019-09-20
期刊：
影响因子：
56.9
通讯作者：
Yamanaka, Akihiro
中科院分区：
文献类型：
--
作者：
Izawa, Shuntaro;Chowdhury, Srikanta;Yamanaka, Akihiro
睡眠中记忆调节的神经机制尚未完全了解。我们发现，下丘脑中的黑色素集中激素产生神经元（MCH神经元）积极促进快速眼动（REM）睡眠中的遗忘。下丘脑MCH神经元密集支配海马背侧。激活或抑制MCH神经元分别损害或改善海马依赖性记忆。体外MCH神经末梢的激活通过增加抑制性输入减少海马锥体神经元的放电。清醒和快速眼动睡眠活跃的MCH神经元是不同的群体，随机分布在下丘脑。快速眼动睡眠状态依赖性抑制MCH神经元损害海马依赖记忆，但不影响睡眠结构或质量。因此，下丘脑的快速眼动睡眠活跃的MCH神经元参与了海马体的活跃遗忘。
The neural mechanisms underlying memory regulation during sleep are not yet fully understood. We found that melanin concentrating hormone-producing neurons (MCH neurons) in the hypothalamus actively contribute to forgetting in rapid eye movement (REM) sleep. Hypothalamic MCH neurons densely innervated the dorsal hippocampus. Activation or inhibition of MCH neurons impaired or improved hippocampus-dependent memory, respectively. Activation of MCH nerve terminals in vitro reduced firing of hippocampal pyramidal neurons by increasing inhibitory inputs. Wake-and REM sleep-active MCH neurons were distinct populations that were randomly distributed in the hypothalamus. REM sleep state-dependent inhibition of MCH neurons impaired hippocampus-dependent memory without affecting sleep architecture or quality. REM sleep-active MCH neurons in the hypothalamus are thus involved in active forgetting in the hippocampus.