Association between thyroid autoimmunity and ovarian reserve in women with hypothyroidism.
Association between thyroid autoimmunity and ovarian reserve in women with hypothyroidism.
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DOI：
10.1186/s13044-021-00095-0
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发表时间：
2021-03-22
期刊：
影响因子：
2.2
通讯作者：
Vidal-Gutierez O
中科院分区：
文献类型：
--
作者：
Morales-Martínez FA;Sordia-Hernández LH;Ruiz MM;Garcia-Luna S;Valdés-Martínez OH;Vidal-Gutierez O
自身免疫性疾病的发病机制可能会损害卵巢功能，从而影响卵巢储备，其中桥本甲状腺炎（HT）在育龄妇女中最常见。此外，甲状腺激素浓度的长期降低导致广泛的生殖改变。以往的文献报道对甲状腺功能减退和卵巢储备功能改变的影响存在争议。因此，本前瞻性比较研究旨在评估甲状腺功能减退症与卵巢储备功能低下的关系。将27例原发性自身免疫性甲状腺功能减退症患者与健康女性进行比较。通过抗苗勒管激素（AMH）和窦卵泡计数（AFC）评估卵巢储备。总的来说，两组在月经周期的长度方面没有显着差异，无论是AMH血清水平还是AFC。HT患者卵巢储备功能无明显改变。
The ovarian function and therefore the ovarian reserve may be compromised by the pathogenesis of autoimmune diseases of which, Hashimoto’s thyroiditis (HT) is the most common in women of reproductive age. Furthermore, a prolonged reduction in thyroid hormone concentration results in a broad spectrum of reproductive alteration. Previous reports in the literature have been controversial regarding the impact of hypothyroidism and alterations in the ovarian reserve. Thus, this prospective and comparative study aimed to evaluate the association of hypothyroidism with low ovarian reserve. A subset of 27 patients with primary autoimmune hypothyroidism were compared to healthy women. The ovarian reserve was assessed through the anti-Mullerian hormone (AMH) and the antral follicle count (AFC). Overall, the two groups did not display significant differences in length of their menstrual cycles neither in the AMH serum levels nor the AFC. No significant alteration was found in the ovarian reserve of women with HT.