Yield of Noncardiac Biopsy for the Diagnosis of Transthyretin Cardiac Amyloidosis
Yield of Noncardiac Biopsy for the Diagnosis of Transthyretin Cardiac Amyloidosis
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DOI：
10.1016/j.amjcard.2014.02.030
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发表时间：
2014-05-15
影响因子：
2.8
通讯作者：
Grogan, Martha
中科院分区：
文献类型：
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作者：
Fine, Nowell M.;Arruda-Olson, Adelaide M.;Grogan, Martha
甲状腺素运载蛋白（ATTR）心脏淀粉样变性可能是由于甲状腺素运载蛋白突变引起家族性淀粉样心肌病（FAC）或轻度甲状腺素运载蛋白引起系统性老年淀粉样变性（SSA）。组织学确认通常具有挑战性，可能需要肌内膜活检（EMB）。本研究的目的是确定ATTR心脏淀粉样变性患者非心脏器官活检或脂肪抽吸阳性中淀粉样蛋白沉积的频率。我们回顾了286例（平均年龄66 ± 11岁，85%为男性）在我们机构接受非心脏活检或皮下脂肪抽吸诊断为ATTR心脏淀粉样变性的患者的病历，其中包括186例（65%）FAC和100例（35%）SSA。131例（46%）患者有EMB，均为阳性。210例（73%）非心脏组织取样阳性，包括175例（94%）FAC和35例（35%）SSA（p
Transthyretin (ATTR) cardiac amyloidosis may be because of mutant transthyretin causing familial amyloid cardiomyopathy (FAC) or mild-type transthyretin causing systemic senile amyloidosis (SSA). Histologic confirmation is often challenging and may require endomyocardial biopsy (EMB). The purpose of this study was to determine the frequency of amyloid protein deposition in positive noncardiac organ biopsy or fat aspiration in patients with ATTR cardiac amyloidosis. The medical records of 286 patients (mean age 66 11, 85% men) with a diagnosis of ATTR cardiac amyloidosis at our institution who underwent noncardiac biopsy or subcutaneous fat aspiration were reviewed, including 186 patients (65%) with FAC and 100 patients (35%) with SSA. One hundred and thirty-one patients (46%) had EMB, all of which were positive. There were 210 patients (73%) with positive noncardiac tissue sampling, including 175 patients (94%) with FAC and 35 patients (35%) with SSA (p