The process of mRNA-tRNA translocation
The process of mRNA-tRNA translocation
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DOI：
10.1073/pnas.0708517104
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发表时间：
2007-12-11
影响因子：
11.1
通讯作者：
Taylor, Derek J.
中科院分区：
文献类型：
--
作者：
Frank, Joachim;Gao, Haixiao;Taylor, Derek J.
随着最初的低分辨率图被亚纳米范围内的密度图所取代，核糖体及其配体构象变化的证据被发现，定性描述越来越多地被基于 X 射线结构拟合和对接的定量测量所取代。因此，我们可以开始拼凑机械模型，以结构术语解释过去五年核糖体研究中收集的动力学、遗传和其他数据。
As the initially low-resolution maps gave way to density maps in the subnanometer range, evidence of conformational changes both in the ribosome and its ligands was uncovered, and qualitative descriptions were increasingly replaced by quantitative measurements based on fitting and docking of x-ray structures. As a result, we can begin to piece together mechanistic models that explain kinetic, genetic, and other data collected over the five decades of ribosome research in structural terms.