Complete genome sequence of Mycobacterium tuberculosis K from a Korean high school outbreak, belonging to the Beijing family
Complete genome sequence of Mycobacterium tuberculosis K from a Korean high school outbreak, belonging to the Beijing family
复制标题
DOI：
10.1186/s40793-015-0071-4
复制
发表时间：
2015-10-14
影响因子：
--
通讯作者：
Shin, Sung Jae
中科院分区：
文献类型：
--
作者：
Han, Seung Jung;Song, Taeksun;Shin, Sung Jae
结核分枝杆菌K是北京家族的一员，于1999年首次在韩国被鉴定为M临床分离株中最流行的基因型。结核病在高中爆发M.结核杆菌K是一种需氧、非运动、革兰氏阳性和非孢子形成的杆状杆菌。透射电子显微镜分析显示了丰富的脂体在胞质溶胶。对M.使用两种独立的测序方法（桑格和Illumina）对结核病K菌株进行测序。在这里，我们提出了4，385，518 bp长的M的全基因组序列的基因组特征。结核杆菌K（1条染色体，无质粒，G + C含量为65.59%）及其注释，共包含4194个基因（3447个预测功能基因），48个RNA基因（3个rRNA和45个tRNA），261个肽信号基因。
Mycobacterium tuberculosis K, a member of the Beijing family, was first identified in 1999 as the most prevalent genotype in South Korea among clinical isolates of M. tuberculosis from high school outbreaks. M. tuberculosis K is an aerobic, non-motile, Gram-positive, and non-spore-forming rod-shaped bacillus. A transmission electron microscopy analysis displayed an abundance of lipid bodies in the cytosol. The genome of the M. tuberculosis K strain was sequenced using two independent sequencing methods (Sanger and Illumina). Here, we present the genomic features of the 4,385,518-bp-long complete genome sequence of M. tuberculosis K (one chromosome, no plasmid, and 65.59 % G + C content) and its annotation, which consists of 4194 genes (3447 genes with predicted functions), 48 RNA genes (3 rRNA and 45 tRNA) and 261 genes with peptide signals.