Effects of misspecification of allele frequencies on the power of Haseman-Elston sib-pair linkage method for quantitative traits
Effects of misspecification of allele frequencies on the power of Haseman-Elston sib-pair linkage method for quantitative traits
复制标题
DOI：
10.1002/ajmg.1566.abs
复制
发表时间：
2001-11-01
期刊：
影响因子：
--
通讯作者：
Bailey-Wilson, JE
中科院分区：
文献类型：
--
作者：
Mandal, DM;Wilson, AF;Bailey-Wilson, JE
众所周知，Haseman-Elston（H-E）同胞对连锁方法并不假定性状表型的遗传模型是准确无误的，尽管这种假设是针对标记基因座作出的。然而，当某些或所有亲本基因型未知时，标记位点的等位基因频率的错误指定会降低功效。在这项研究中，H-E同胞对方法的权力进行了比较，不同类型的性状时，一些或所有的亲本数据丢失和标记位点的等位基因频率被错误指定。使用G. A. S. P.（V3.3）生成核心家系中数量性状和标记基因座的数据。用两个等位基因模拟了三种类型的性状，随机环境效应（10%，30%和50%）。使用（i）亲本的标记数据之一，和（ii）无亲本标记数据，使用正确和不正确的标记等位基因频率分析模拟数据。这个测试被认为是强大的，在大多数情况下，除了权力略有下降时，样本量小，当标记位点不是很多态性。出版于2001年Wiley-Liss，Inc.（匕首）。
It is well known that the Haseman-Elston (H-E) sib-pair linkage method does not assume that the genetic model underlying the trait phenotype is known without error, although this assumption is made for marker loci. However, misspecification of allele frequencies at the marker locus decreases power when some or all parental genotypes are unknown. In this study, the power of the H-E sib-pair method was compared for different types of traits when some or all parental data were missing and allele frequencies at the marker loci were misspecified. Data were generated for a quantitative trait and marker loci in nuclear families using G.A.S.P. (V3.3). Three types of traits were simulated with two equifrequent alleles with a random environmental effect (10%, 30%, and 50%). The simulated data were analyzed using (i) one of the parent's marker data, and (ii) no parental marker data, with both correct and incorrect marker allele frequencies. This test is found to be robust in most of the situations considered except for a slight decrease in power when sample size is small and when the marker locus is not very polymorphic. Published 2001 Wiley-Liss, Inc.(dagger).