Homeostasis during hypoglycemia: central control of adrenal secretion and peripheral control of feeding.
Homeostasis during hypoglycemia: central control of adrenal secretion and peripheral control of feeding.
复制标题
低血糖期间的稳态：肾上腺分泌的中枢控制和进食的外周控制。
作者：
E. Stricker;N. Rowland;C. Saller;M. Friedman
静脉输注甘露糖或B-羟基丁酸酯，代谢燃料，可以被大脑氧化，废除肾上腺分泌肾上腺素的大鼠在胰岛素诱导的低血糖症，而果糖，糖不穿过血脑屏障的输液，没有。相反，在低血糖期间增加的进食行为被糖和B-羟基丁酸盐阻止。因此，虽然显著低血糖期间的交感神经反应可能是由大脑代谢的改变引起的，但进食反应显然不是，葡萄糖利用率的降低本身似乎不是这两种情况下的关键刺激。
Intravenous infusions of manose or B-hydroxybutyrate, metabolic fuels which can be oxidized by brain, abolished adrenal discharge of epinephrine in rats during insulin-induced hypoglycemia, whereas infusion of fructose, a sugar which does not cross the blood-brain barrier, did not. In contrast, increased feeding behavior during hypoglycemia was prevented both by the sugars and by B-hydroxybutyrate. Thus, while the sympathetic response during marked hypoglycemia may have been initiated by alterations in cerebal metabolism, the feeding response evidently was not, and a decrease in the utilization of glucose per se does not appear to be the critical stimulus in either case.