Cytolethal distending toxin in Escherichia coli O157:H7:: Spectrum of conservation, structure, and endothelial toxicity
Cytolethal distending toxin in Escherichia coli O157:H7:: Spectrum of conservation, structure, and endothelial toxicity
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DOI：
10.1128/jcm.44.5.1844-1846.2006
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发表时间：
2006-05-01
影响因子：
9.4
通讯作者：
Karch, Helge
中科院分区：
文献类型：
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作者：
Friedrich, Alexander W.;Lu, Shan;Karch, Helge
我们在391株肠出血性大肠杆菌O157：H7中的19株(4.9%)中发现了细胞致死性膨胀毒素V(CDT-V)基因簇。CDT-V+菌株分属5个噬菌体类型(VI‘s)，以pT14和pT34最多见。CDT-V在除两株CDT-V+外的所有菌株中均有表达，并对培养的内皮细胞具有致死性。亚型方案应包括CDT-V作为标记，以区分大肠杆菌O157：H7，即使在同一噬菌体类型中也是如此。
We identified the cytolethal distending toxin V (CDT-V) gene cluster in 19 (4.9%) of 391 enterohemorrhagic Escherichia coli O157:H7. cdt-V+ strains belonged to five phage types (VI's) and were most frequent within PTs 14 and 34. CDT-V was expressed in all but two cdt-V+ strains and was lethal to cultured endothelial cells. Subtyping schemes should include cdt-V as a marker to differentiate E. coli O157:H7 even within the same phage type.