TRANSPORT AND STORAGE OF VITAMIN-A
TRANSPORT AND STORAGE OF VITAMIN-A
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DOI：
10.1126/science.2218545
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发表时间：
1990-10-19
期刊：
影响因子：
56.9
通讯作者：
NORUM, KR
中科院分区：
文献类型：
--
作者：
BLOMHOFF, R;GREEN, MH;NORUM, KR
几十年来，人们已经认识到维生素A(维甲酸)对视力的需求。此外，维生素A还参与胎儿发育，并在整个生命过程中调节细胞的增殖和分化。这种脂溶有机化合物不能由人类内源性合成，因此是一种基本的营养物质；尽管每日维生素A摄入量正常波动，但良好调节的运输和储存系统为组织提供正确数量的维甲酸。本文对维生素A的吸收、运输、储存和代谢的现有知识和假说进行了综述，并介绍了一组配体依赖的转录因子--视黄酸受体的一些信息，这些转录因子显然介导了视黄酸类物质的许多视觉外效应。
The requirement of vitamin A (retinoids) for vision has been recognized for decades. In addition, vitamin A is involved in fetal development and in the regulation of proliferation and differentiation of cells throughout life. This fat-soluble organic compound cannot be synthesized endogenously by humans and thus is an essential nutrient; a well-regulated transport and storage system provides tissues with the correct amounts of retinoids in spite of normal fluctuations in daily vitamin A intake. An overview is presented here of current knowledge and hypotheses about the absorption, transport, storage, and metabolism of vitamin A. Some information is also presented about a group of ligand-dependent transcription factors, the retinoic acid receptors, that apparently mediate many of the extravisual effects of retinoids.