Matter of Fat: Are Lipids Antiarrhythmic?
Matter of Fat: Are Lipids Antiarrhythmic?
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脂肪问题：脂质具有抗心律失常作用吗？
DOI：
10.1161/circep.115.003636
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Boyden,PenelopeA
中科院分区：
文献类型：
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作者：
Wan,Elaine;Boyden,PenelopeA
1314 Circ Arrhythmia Electrophysiol 2015年12月在相同心脏中启动（触发）。心肌梗死后，梗死区域内的细胞处于不同的去极化阶段。在缺血区的中心，细胞去极化并死亡，而在外周，细胞可能部分去极化，因此可能更兴奋。在心肌梗死后的急性期，儿茶酚胺的激增被认为是通过激活内皮素-1触发室性心律失常。因此，这些事件仍有可能发生。此外，在LDLr−/−和ApoA 1 −/−心肌细胞中存在增强的Ca 2+电流的情况下，更可能发生延迟后除极和早期后除极。
1314 Circ Arrhythm Electrophysiol December 2015 initiation (triggers) in the same hearts. After an MI, cells within the region of infarction are in different stages of depolarization. In the center of the ischemic zone, cells depolarize and die, whereas in the periphery, cells may be partially depolarized and, therefore, may be more excitable. During the acute time period post MI, the surge in catecholamines is thought to trigger ventricular arrhythmias through activation of endothelin-1. Thus, it is possible that these events still occur. Furthermore, in the presence of enhanced Ca2+ currents in the LDLr−/− and ApoA1−/− myocytes, delayed afterdepolarizations and early afterdepolarizations are more likely to occur.