Total syntheses via cyclopropanols
Total syntheses via cyclopropanols
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DOI：
10.1016/j.tet.2018.11.026
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发表时间：
2019-01-11
期刊：
影响因子：
2.1
通讯作者：
Dai, Mingji
中科院分区：
文献类型：
--
作者：
Cai, Xinpei;Liang, Weida;Dai, Mingji
环丙醇很容易通过库林科维奇环丙化、西蒙斯-史密斯反应和其他合成方法得到。由于其固有的环状染色，环丙醇及其衍生物具有高活性，可以转化为不同的结构支架，这在许多天然产物中经常发现。本文综述了各种环丙醇开环/膨胀/裂解反应在天然产物全合成中的应用。(C) 2018 Elsevier Ltd.版权所有。
Cyclopropanols are readily available via the Kulinkovich cyclopropanation, the Simmons-Smith reaction, and other synthetic methods. Due to their intrinsic ring stains, cyclopropanols and their derivatives are highly reactive and can be converted to different structural scaffolds which are frequently found in many natural products. In this review, we highlight the applications of various cyclopropanol ring opening/expansion/fragmentation reactions in the total syntheses of natural products. (C) 2018 Elsevier Ltd. All rights reserved.