Lactococcus lactis As a Versatile Vehicle for Tolerogenic Immunotherapy.
Lactococcus lactis As a Versatile Vehicle for Tolerogenic Immunotherapy.
复制标题
乳酸乳酸作为耐受性免疫疗法的多功能载体。
DOI：
10.3389/fimmu.2017.01961
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发表时间：
2017
影响因子：
7.3
通讯作者：
Mathieu C
中科院分区：
文献类型：
--
作者：
Cook DP;Gysemans C;Mathieu C
基因修饰的乳酸乳球菌细菌已经被设计为将生物活性蛋白递送到粘膜组织的工具，作为发挥局部和全身作用的手段。它们具有良好的安全性，这是多年来食品工业中人类消费的结果，并且缺乏毒性和免疫原性。此外，遏制策略已被开发，以促进进一步应用作为临床蛋白质为基础的治疗。在这里，我们回顾了技术进步，以提高L。乳酸菌作为活的生物工厂，并讨论了一些例子，耐受性免疫疗法介导的粘膜药物输送通过乳酸菌。乳酸。此外，我们强调了它们通过靶向自身抗原递送到肠道来诱导粘膜耐受的用途，作为逆转自身免疫性1型糖尿病的方法。
Genetically modified Lactococcus lactis bacteria have been engineered as a tool to deliver bioactive proteins to mucosal tissues as a means to exert both local and systemic effects. They have an excellent safety profile, the result of years of human consumption in the food industry, as well as a lack of toxicity and immunogenicity. Also, containment strategies have been developed to promote further application as clinical protein-based therapeutics. Here, we review technological advancements made to enhanced the potential of L. lactis as live biofactories and discuss some examples of tolerogenic immunotherapies mediated by mucosal drug delivery via L. lactis. Additionally, we highlight their use to induce mucosal tolerance by targeted autoantigen delivery to the intestine as an approach to reverse autoimmune type 1 diabetes.