Effects of polychlorinated biphenyls on maternal odor conditioning in rat pups
Effects of polychlorinated biphenyls on maternal odor conditioning in rat pups
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DOI：
10.1016/j.physbeh.2007.03.029
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发表时间：
2007-08-15
影响因子：
2.9
通讯作者：
Meserve, Lee A.
中科院分区：
文献类型：
--
作者：
Cromwell, Howard C.;Johnson, Asia;Meserve, Lee A.
多氯联苯（PCBs）是一种普遍存在的环境污染物，可对生理、运动和认知功能产生破坏性影响。对多氯联苯和行为的研究结果表明，接触多氯联苯会改变学习和记忆过程，这些认知能力的变化可能与荷尔蒙和神经功能的变化有关。关于接触多氯联苯对社会和情感发展的影响，几乎没有做过实验。之前的工作表明，儿童接触多氯联苯会改变游戏行为。重要的是，暴露于多氯联苯已被发现改变啮齿动物的母子互动方面。本研究探讨了多氯联苯对12-14日龄幼鼠的母性气味调节的影响。一个修改后的版本的条件性位置偏好范式，采用了与母亲相关的气味线索（柠檬气味）作为条件刺激。多氯联苯显着压抑的偏好与母亲有关的线索，但并没有损害歧视的新气味。这些影响可能会出现由于社会动态之间的变化，在共同暴露于多氯联苯的母亲和后代。例如，在怀孕期间接触多氯联苯的母鼠对接触多氯联苯的幼鼠的梳理行为有所增加。这种母亲护理的变化会对发育中的幼鼠的行为和激素系统产生巨大影响。总之，围产期多氯联苯改变了母亲和幼崽的重要社会行为，这些改变可能对行为，认知和情感发育产生长期影响。(C)2007年爱思唯尔公司All rights reserved.
Polychlorinated biphenyls (PCBs) are pervasive environmental contaminants that can have damaging effects on physiologic, motoric and cognitive function. Results from studies on PCBs and behavior have shown that exposure can alter learning and memory processes and that these shifts in cognitive abilities can be related to changes in hormonal and neural function. Little experimentation has been done on the impact of exposure to PCBs on social and emotional development. Previous work has shown that exposure to PCBs in children can alter play behavior. Importantly, exposure to PCBs has been found to change aspects of maternal-offspring interactions in rodents. The present study examined the impact of PCBs on maternal odor conditioning in rat pups 12-14 days of age. A modified version of the conditioned place preference paradigm was used that incorporated a maternal-associated odor cue (lemon scent) as the conditioned stimulus. PCBs significantly depressed the preference for the maternal-associated cue but did not impair discrimination for a novel odor. These effects could arise due to changes in the social dynamics between the dam and offspring after co-exposure to PCBs. For example, dams exposed to PCBs during gestation have been found to show elevated grooming directed towards pups exposed to PCBs. This change in maternal care can have dramatic effects on behavioral and hormonal systems in the developing rat pup. In conclusion, perinatal PCBs alter important social behaviors of both the mother and pup, and these alterations could have long-lasting effects on behavioral, cognitive and emotional development. (C) 2007 Elsevier Inc. All rights reserved.