THE MAGNETIC-PROPERTIES AND WATER DYNAMICS OF THE RED-BLOOD-CELL - A STUDY BY PROTON-NMR LINESHAPE ANALYSIS
THE MAGNETIC-PROPERTIES AND WATER DYNAMICS OF THE RED-BLOOD-CELL - A STUDY BY PROTON-NMR LINESHAPE ANALYSIS
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DOI：
10.1002/mrm.1910260208
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发表时间：
1992-08-01
影响因子：
3.3
通讯作者：
MATWIYOFF, NA
中科院分区：
文献类型：
--
作者：
GASPAROVIC, C;MATWIYOFF, NA
通过分析在7.05 T磁场强度下含氧、脱氧、一氧化碳处理和高铁血红蛋白的细胞悬浮液的水质子谱，检查人红细胞的磁性和水动力学。对脱氧红细胞悬液的光谱进行总线形分析，以确定跨膜水交换速率、局部磁场梯度中扩散对横向弛豫速率的贡献以及水质子的细胞内和细胞外化学位移之间的差异。提出了数学模型来解释这些光谱的化学位移和线宽对磁化率或细胞密度的依赖性。
The magnetic properties and water dynamics of human red blood cells were examined by analysis of the water proton spectra of suspensions of oxygenated, deoxygenated, carbon monoxide‐treated, and methemoglobin‐containing cells at a magnetic field strength of 7.05 T. Total lineshape analysis of spectra from deoxygenated red blood cell suspensions was performed to determine the transmembrane water exchange rate, the contribution of diffusion in local magnetic field gradients to the transverse relaxation rate, and the difference between the intra‐and extracellular chemical shifts of water protons. Mathematical models are proposed to account for the dependence of the chemical shifts and linewidths of these spectra on the magnetic susceptibility or density of the cells.