PROTECTIVE ACTION OF 7 NATURAL PHENOLIC-COMPOUNDS AGAINST PEROXIDATIVE DAMAGE TO BIOMEMBRANES
PROTECTIVE ACTION OF 7 NATURAL PHENOLIC-COMPOUNDS AGAINST PEROXIDATIVE DAMAGE TO BIOMEMBRANES
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DOI：
10.1016/0006-2952(92)90271-j
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发表时间：
1992-01-22
影响因子：
5.8
通讯作者：
WANG, YW
中科院分区：
文献类型：
--
作者：
LIU, GT;ZHANG, TM;WANG, YW
研究了从丹参中分离出的七种酚类化合物对大鼠肝微粒体、肝细胞和红细胞的过氧化损伤的影响。结果表明，这七种化合物抑制了铁/半胱氨酸和维生素C/NADPH诱导的大鼠肝微粒体脂质过氧化，也抑制了过氧化氢诱导的大鼠红细胞溶血，抑制程度因化合物不同而异。在这七种化合物中，丹酚酸（Sia A）的作用最强。因此，进一步评估了Sai A对分离的大鼠肝细胞及其质膜过氧化损伤的保护作用。Sai A可防止铁/半胱氨酸诱导的大鼠肝细胞丙二醛（MDA）产生和表面起泡，也抑制了铁/半胱氨酸和维生素C/NADPH引发脂质过氧化过程中质膜MDA的产生和NADPH的消耗。结果有力地表明，像Sai A这样的几种酚类化合物对生物膜的过氧化损伤具有保护作用。
The effects of seven phenolic compounds isolated from Salvia miltiorrhiza and peroxidative damage to liver microsomes, hepatocytes and erythrocytes of rats were studied. The results show that the seven compounds inhibited lipid peroxidation of rat liver microsomes induced by iron/cysteine and Vitamin C/NADPH. The hemolysis of rate erythrocytes induced by hydrogen peroxide was also inhibited. The degree of inhibition varied with different compounds. Among the seven compounds, the action of salvianolic acid (Sia A) was the most potent. Therefore, the protective action of Sai A against peroxidative damage to isolated rat hepatocytes and their plasma membranes was evaluated further. Malondialdehyde (MDA) production and bleb of the surface of rat hepatocytes induced by iron/cysteine were prevented by Sai A. The production of MDA and the consumption of NADPH of the plasma membrane during lipid peroxidation initiated by iron/cysteine and Vitamin C/NADPH were also inhibited. The results strongly suggest that several phenolic compounds like Sai A have a protective action against peroxidative damage to biomembranes.