Efficient enantioselective synthesis of (2R,3R)- and (2S,3S)-3-hydroxyleucines and their diastereomers through dynamic kinetic resolution
Efficient enantioselective synthesis of (2R,3R)- and (2S,3S)-3-hydroxyleucines and their diastereomers through dynamic kinetic resolution
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DOI：
10.1016/s0957-4166(01)00306-8
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发表时间：
2001-07-16
影响因子：
--
通讯作者：
Hamada, Y
中科院分区：
文献类型：
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作者：
Makino, K;Okamoto, N;Hamada, Y
利用RuCl2(BINAP)催化的氢化反应，从相应的β-酮基-α-氨基酸酯出发，通过动力学Z‘拆分，有效地合成了(2R，3R)-和(2S，3S)-3-羟基亮氨酸及其非对映异构体。(C)2001爱思唯尔科学有限公司。保留所有权利。
(2R,3R)- and (2S,3S)-3-Hydroxyleucines, components of cyclodepsipeptides, papuamides and polyoxypeptins, were efficiently synthesized along with their diastereomers from the corresponding beta -keto-alpha -amino acid ester through dynamic kinetic Z ' resolution using RuCl2(binap)-catalyzed hydrogenation. (C) 2001 Elsevier Science Ltd. All rights reserved.