Overlapping nongenomic and genomic actions of thyroid hormone and steroids
Overlapping nongenomic and genomic actions of thyroid hormone and steroids
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DOI：
10.1016/j.beem.2015.04.001
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发表时间：
2015-08-01
影响因子：
7.4
通讯作者：
Davis, Paul J.
中科院分区：
文献类型：
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作者：
Hammes, Stephen R.;Davis, Paul J.
甲状腺激素和类固醇的基因组作用取决于激素与其特异性核受体蛋白的初级相互作用。涉及配体受体的核辅激活子或辅抑制子复合物的形成随后导致作为甲状腺激素或类固醇的特异性靶点的基因的转录事件激活或抑制。相反，甲状腺激素和类固醇的非基因组作用起始于质膜或细胞质或细胞器上的结合位点，并且主要不需要形成核内受体蛋白-激素复合物。重要的是，激素的行动，开始非基因组的细胞核外，往往最终在核转录事件的变化，这是由传统的核内受体以及其他核转录因子。在甲状腺激素的情况下，胞核受体可以是经典的“核”甲状腺受体（TR）、TR同种型或整联蛋白硬币。在类固醇激素的情况下，膜受体通常是但不总是经典的“核”类固醇受体。这个概念定义了重叠的非基因组和基因组激素作用机制的范例。在这里，我们回顾了甲状腺激素和雌激素和雄激素如何调节核内激素信号传导的一些例子，以调节正常生理和癌症进展中的一些重要的生物学过程。我们还指出，甲状腺激素的非基因组作用可能会模拟某些肿瘤中雌激素的作用。(C)2015作者爱思唯尔有限公司出版
The genomic actions of thyroid hormone and steroids depend upon primary interactions of the hormones with their specific nuclear receptor proteins. Formation of nuclear co-activator or co-repressor complexes involving the liganded receptors subsequently result in transcriptional events-either activation or suppression-at genes that are specific targets of thyroid hormone or steroids. Nongenomic actions of thyroid hormone and steroids are in contrast initiated at binding sites on the plasma membrane or in cytoplasm or organelles and do not primarily require formation of intranuclear receptor protein-hormone complexes. Importantly, hormonal actions that begin nongenomically outside the nucleus often culminate in changes in nuclear transcriptional events that are regulated by both traditional intranuclear receptors as well as other nuclear transcription factors. In the case of thyroid hormone, the extranuclear receptor can be the classical "nuclear" thyroid receptor (TR), a TR isoform, or integrin coin In the case of steroid hormones, the membrane receptor is usually, but not always, the classical "nuclear" steroid receptor. This concept defines the paradigm of overlapping nongenomic and genomic hormone mechanisms of action. Here we review some examples of how extranuclear signaling by thyroid hormone and by estrogens and androgens modulates intranuclear hormone signaling to regulate a number of vital biological processes both in normal physiology and in cancer progression. We also point out that nongenomic actions of thyroid hormone may mimic effects of estrogen in certain tumors. (C) 2015 The Authors. Published by Elsevier Ltd.