Viral etiology of sporadic cases of parotitis among children in Korea during 2013-2014
Viral etiology of sporadic cases of parotitis among children in Korea during 2013-2014
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DOI：
10.1002/jmv.24935
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发表时间：
2018-01-01
影响因子：
12.7
通讯作者：
Kim, Sung S.
中科院分区：
文献类型：
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作者：
Kang, Hae J.;Kim, Sun H.;Kim, Sung S.
近年来，腮腺炎的发病率很高，通常根据临床特征，特别是腮腺炎进行诊断，在韩国没有实验室确认。为了更好地了解韩国儿童流行性腮腺炎的流行病学，我们调查了散发的腮腺炎疑似病例。总共使用实时PCR检测了从临床诊断为腮腺炎的腮腺炎儿童中采集的237份口腔拭子或咽拭子，以检测6种病毒（EB病毒、人疱疹病毒6型、腮腺炎病毒、人副流感病毒-1、-2、-3、人腺病毒、人博卡病毒）。在237例腮腺炎病例中，87例（36.7%）至少对一种病毒呈阳性; 73例（83.9%）病例中观察到单一感染，14例（16.1%）病例中检测到合并感染。EB病毒最常见（20.7%），其次是人类疱疹病毒6型（8.0%）、腮腺炎病毒（5.5%）、人类副流感病毒-3型（4.6%）、人类腺病毒（4.2%）和人类博卡病毒（0.4%）。这些数据表明，儿童散发的疑似腮腺炎可能与其他呼吸道病毒有关，而不是腮腺炎病毒。我们的研究结果还表明，没有实验室确认的腮腺炎临床诊断的局限性，因此强调了实验室检测在疑似腮腺炎病例中的重要性。
Recent years have seen a high incidence of mumps, which is generally diagnosed based on clinical features, especially parotitis, without laboratory confirmation in Korea. To better understand the epidemiology of mumps in Korean children, we investigated sporadic suspected mumps cases with parotitis. In total, 237 buccal swabs or throat swabs collected from children with parotitis who had been clinically diagnosed with mumps were tested using real-time PCR for the detection of six viruses (Epstein-Barr virus, Human herpesvirus 6, Mumps virus, Human parainfluenza virus-1, -2, -3, Human adenovirus, Human bocavirus). Among 237 parotitis cases, 87 (36.7%) were positive for at least one virus; a single infection was observed in 73 (83.9%) cases, and co-infections were detected in 14 (16.1%) cases. Epstein-Barr virus was most frequent (20.7%), followed by human herpesvirus 6 (8.0%), mumps virus (5.5%), human parainfluenza virus-3 (4.6%), human adenovirus (4.2%), and human bocavirus (0.4%). These data suggested that the sporadic suspected mumps in the children might be related to other respiratory viruses rather than to the mumps virus. Our findings also indicate the limitation of clinical diagnosis without laboratory confirmation for mumps and thus highlight the importance of laboratory testing in suspected mumps cases.