POTENTIAL OF VISUAL-CORTEX TO DEVELOP AN ARRAY OF FUNCTIONAL UNITS UNIQUE TO SOMATOSENSORY CORTEX
POTENTIAL OF VISUAL-CORTEX TO DEVELOP AN ARRAY OF FUNCTIONAL UNITS UNIQUE TO SOMATOSENSORY CORTEX
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DOI：
10.1126/science.2047863
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发表时间：
1991-06-14
期刊：
影响因子：
56.9
通讯作者：
OLEARY, DDM
中科院分区：
文献类型：
--
作者：
SCHLAGGAR, BL;OLEARY, DDM
哺乳动物新皮层中的专门区域的识别，例如初级视觉或躯体感觉皮层，是基于结构和功能特征的区别。 在何种程度上区分大鼠的新皮层区域的某些功能是预先指定的或出现作为表观遗传相互作用的结果进行了研究。 晚期胚胎视觉皮层移植到新生儿的躯体感觉皮层，后来分析的“桶”，解剖学上确定的功能单位独特的躯体感觉皮层，和边界的糖结合分子与桶。 桶和边界在移植的视觉皮层中形成，并组织成一个类似于正常桶场模式的阵列。 这些发现表明，不同地区的发展新皮层有类似的潜力，区分功能，区分新皮层地区，并有助于其独特的功能组织。
The identification of specialized areas in the mammalian neocortex, such as the primary visual or somatosensory cortex, is based on distinctions in architectural and functional features. The extent to which certain features that distinguish neocortical areas in rats are prespecified or emerge as a result of epigenetic interactions was investigated. Late embryonic visual cortex transplanted to neonatal somatosensory cortex was later assayed for "barrels," anatomically identified functional units unique to somatosensory cortex, and for boundaries of glycoconjugated molecules associated with barrels. Barrels and boundaries form in transplanted visual cortex and are organized in an array that resembles the pattern in the normal barrelfield. These findings show that different regions of the developing neocortex have similar potentials to differentiate features that distinguish neocortical areas and contribute to their unique functional organizations.