Relationship of Circulating Anti-C3b and Anti-C1q IgG to Lupus Nephritis and Its Flare
Relationship of Circulating Anti-C3b and Anti-C1q IgG to Lupus Nephritis and Its Flare
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DOI：
10.2215/cjn.03990415
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发表时间：
2016-01-01
影响因子：
9.8
通讯作者：
Hebert, Lee A.
中科院分区：
文献类型：
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作者：
Birmingham, Daniel J.;Bitter, Joshua E.;Hebert, Lee A.
背景与目的补体C1 q自身抗体（anti-C1 q）与狼疮性肾炎的诊断相关。在本研究中，我们将抗C1 q IgG与另一种补体自身抗体抗C3 b IgG进行比较。作为狼疮性肾炎和狼疮性肾炎发作的生物标志物。设计、设置、参与者和测量我们的研究涉及俄亥俄州SLE研究，这是一项前瞻性观察性队列研究，对患有复发性活动性狼疮的患者每两个月进行一次随访。在俄亥俄州SLE研究中，通过ELISA对40名正常对照和114名患者的血清抗C1 q和抗C3 b IgG水平进行了横断面评估（41例非肾性和73例狼疮性肾炎），在俄亥俄州SLE研究中，抗C1 q阳性狼疮肾炎患者亚组中，在狼疮肾炎发作前每2个月采集一次样本，持续8个月结果在横断面分析中，与抗C1 q IgG相比，抗C3 b IgG对狼疮性肾炎的敏感性较低（36%比63%），但特异性较高（98%比71%）。在俄亥俄州SLE研究期间，只有抗C3 b IgG与至少发生一次狼疮性肾炎发作的狼疮性肾炎患者相关（P
Background and objectives Autoantibodies to complement C1q (anti-C1q) are associated with the diagnosis of lupus nephritis. In this study, we compare anti-C1q IgG with another complement autoantibody, anti-C3b IgG,. as a biomarker of lupus nephritis and lupus nephritis flare.Design, setting, participants, & measurements Our investigation involved the Ohio SLE Study, a prospective observational cohort of patients with recurrently active lupus who were followed bimonthly. Serum anti-C1q and anti-C3b IgG levels were assessed cross-sectionally by ELISA in 40 normal controls and 114 patients in the Ohio SLE Study (41 nonrenal and 73 lupus nephritis) at study entry, and longitudinally in a subset of patients in the Ohio SLE Study with anti-C1q positive lupus nephritis in samples collected every 2 months for 8 months leading up to lupus nephritis flare (n=16 patients).Results In the cross-sectional analysis, compared with anti-C1q IgG, anti-C3b IgG was less sensitive (36% versus 63%) but more specific (98% versus 71%) for lupus nephritis. Only anti-C3b IgG was associated with patients with lupus nephritis who experienced at least one lupus nephritis flare during the Ohio SLE Study period (P