Quantitative assessment of aortic sclerosis using ultrasonic backscatter
Quantitative assessment of aortic sclerosis using ultrasonic backscatter
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DOI：
10.1016/j.echo.2004.06.012
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发表时间：
2004-11-01
影响因子：
6.5
通讯作者：
Horowitz, JD
中科院分区：
文献类型：
--
作者：
Ngo, DTM;Wuttke, RD;Horowitz, JD
背景与临床上明显的主动脉瓣狭窄相比，预防进行性瓣膜损伤的治疗干预的发展更可能限制功能正常的主动脉瓣结构性损伤的进展（主动脉硬化[ASC]）。目前，欣赏ASC的进展的能力受到损害的硬化severity.Methods的主观和定性评价：我们试图揭示是否超声背向散射的强度可以用来量化硬化的严重程度在26例ASC和23名健康的年轻人。在胸骨旁长轴视图中获得主动脉瓣的图像，并以原始数据格式保存。将6个方形11 X 11像素的感兴趣区域放置在前叶和后叶上，通过从小叶获得的平均反向散射值中减去血池中的感兴趣区域来获得校准的反向散射值。平均超声背向散射值，scaffold瓣膜超过正常瓣膜组织的结果（16.3 +/- 4.4 dB vs 9.8 +/- 3.3 dB，P <0.0001）。一组6名主动脉瓣狭窄患者的反向散射值更大（22.0 +/- 3.5 dB）。在硬化组中，背向散射强度与主观硬化评分和跨瓣压差直接相关（P <0.05）。平均再现性为2.4 +/- 1.8 dB（SD）之间的观察者，和2.3 +/- 1.7 dB（SD）之间的examination.Conclusion：测量的背向散射从瓣膜小叶的患者与ASC可能是一种可行的手段，以下的进展和治疗反应的主动脉硬化。
Background. The development of therapeutic interventions to prevent progressive valve damage is more likely to limit the progression of structural damage to the aortic valve with normal function (aortic sclerosis [ASC]) than clinically apparent aortic stenosis. Currently, the ability to appreciate the progression of ASC is compromised by the subjective and qualitative evaluation of sclerosis severity.Methods: We sought to reveal whether the intensity of ultrasonic backscatter could be used to quantify sclerosis severity in 26 patients with ASC and 23 healthy young adults. images of the aortic valve were obtained in the parasternal long-axis view and saved in raw data format. Six square-shaped 11 X 11 pixel regions of interest were placed on the anterior and posterior leaflets, and calibrated backscatter values were obtained by subtracting the regions of interest in the blood pool from the averaged backscatter values obtained from the leaflets.Results. Mean ultrasonic backscatter values for sclerotic valves exceeded the results in normal valve tissue (16.3 +/- 4.4 dB vs 9.8 +/- 3.3 dB, P < .0001). Backscatter values were greater (22.0 +/- 3.5 dB) in a group of 6 patients with aortic stenosis. Within the sclerosis group, the magnitude of backscatter was directly correlated (P < .05) with a subjective sclerosis score, and with transvalvular pressure gradient. mean reproducibility was 2.4 +/- 1.8 dB (SD) between observers, and 2.3 +/- 1.7 dB (SD) between examinations.Conclusion: Measurement of backscatter from the valve leaflets of patients with ASC may be a feasible means of following the progression and treatment response of aortic sclerosis.