APPL1 is a multifunctional endosomal signaling adaptor protein.
APPL1 is a multifunctional endosomal signaling adaptor protein.
复制标题
DOI：
10.1042/bst20160191
复制
发表时间：
2017-06-15
影响因子：
3.9
通讯作者：
Webb DJ
中科院分区：
文献类型：
--
作者：
Diggins NL;Webb DJ
内体衔接蛋白是许多生物学过程中信号转导途径的重要调节因子。这些衔接子可以通过定位到特定的内体区室以及通过多种蛋白质-蛋白质相互作用来整合来自多个途径的信号。已经涉及调节信号传导途径的一种这样的衔接蛋白是含有普列克底物蛋白同源（PH）结构域、磷酸酪氨酸结合（PTB）结构域和亮氨酸拉链基序1（APPL 1）的衔接蛋白。APPL 1通过其Bin-Amphiphysin-Rvs（BAR）和PH结构域定位于Rab 5阳性内体的子集，并且其通过其PTB结构域与许多信号传导受体和蛋白质相互作用来协调信号传导途径。本文综述了我们目前对APPL 1在信号传导和运输中的作用的理解，并强调了APPL 1在细胞迁移和粘附中的功能。
Endosomal adaptor proteins are important regulators of signaling pathways underlying many biological processes. These adaptors can integrate signals from multiple pathways via localization to specific endosomal compartments, as well as through multiple protein-protein interactions. One such adaptor protein that has been implicated in regulating signaling pathways is the adaptor protein containing a pleckstrin-homology (PH) domain, phosphotyrosine binding (PTB) domain, and leucine zipper motif 1 (APPL1). APPL1 localizes to a subset of Rab5-positive endosomes through its Bin-Amphiphysin-Rvs (BAR) and PH domains, and it coordinates signaling pathways through its interaction with many signaling receptors and proteins through its PTB domain. This review discusses our current understanding of the role of APPL1 in signaling and trafficking, as well as highlights recent work into the function of APPL1 in cell migration and adhesion.