Iridium-Catalyzed Direct C-H Amidation with Weakly Coordinating Carbonyl Directing Groups under Mild Conditions
Iridium-Catalyzed Direct C-H Amidation with Weakly Coordinating Carbonyl Directing Groups under Mild Conditions
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DOI：
10.1002/anie.201310544
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发表时间：
2014-02-17
影响因子：
16.6
通讯作者：
Chang, Sukbok
中科院分区：
文献类型：
--
作者：
Kim, Jinwoo;Chang, Sukbok
在非常温和的条件下，铱催化弱配位底物，特别是那些含有酯和酮基的底物的直接甲烷酰胺化已被开发出来。以醋酸和碳酸锂为助剂，取得了较高的反应效率。
An iridium-catalyzed direct CH amidation of weakly coordinating substrates, in particular of those bearing ester and ketone groups, under very mild conditions has been developed. The observed high reaction efficiency was achieved by the combined use of acetic acid and lithium carbonate as additives.