EFFECT OF INFLUENZA-A VIRUS ON CILIARY ACTIVITY AND DYE TRANSPORT FUNCTION IN THE CHINCHILLA EUSTACHIAN-TUBE
EFFECT OF INFLUENZA-A VIRUS ON CILIARY ACTIVITY AND DYE TRANSPORT FUNCTION IN THE CHINCHILLA EUSTACHIAN-TUBE
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DOI：
10.1177/000348949310200711
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发表时间：
1993-07-01
影响因子：
1.4
通讯作者：
LIM, DJ
中科院分区：
文献类型：
--
作者：
PARK, K;COTICCHIA, JM;LIM, DJ
以往的研究表明，通过经眼球途径接种甲型流感病毒可导致严重的灰鼠咽鼓管疾病。在这项研究中，我们接种灰鼠鼻内和transblarly与流感病毒（A/阿拉斯加/6/77），以评估这种病毒的影响，对纤毛活动的咽鼓管上皮和咽鼓管运输功能。数据表明，虽然主要病变的性质是无法区分的，不同的接种途径确实影响病毒诱导的组织病理学的时间过程和初始位置。纤毛搏动频率和染料转运功能的分析表明，接种后约7至14天的最大下降，与接种后28天恢复正常功能。光镜和透射电镜观察组织病理学的演变和恢复正常的组织学与功能评估数据相关。
Previous studies have shown that influenza A virus inoculated via a transbullar approach can cause severe disorders of the chinchilla eustachian tube. In this study, we inoculated chinchillas both intranasally and transbullarly with influenza A virus (A/Alaska/6/77) to assess the effect of this virus on both the ciliary activity of eustachian tube epithelium and eustachian tube transport function. Data indicated that while the nature of the major lesions was indistinguishable, the differing routes of inoculation did influence the time course and initial location of virus-induced histopathology. Analysis of ciliary beat frequency and dye transport function indicated a maximal decrease approximately 7 to 14 days postinoculation, with return to normal function by 28 days postinoculation. Light and transmission electron microscopic observations of the evolution of histopathology and return to normal histology correlated well with functional assessment data.