A comparison of brain gene expression levels in domesticated and wild animals.
A comparison of brain gene expression levels in domesticated and wild animals.
复制标题
DOI：
10.1371/journal.pgen.1002962
复制
发表时间：
2012-09
期刊：
影响因子：
4.5
通讯作者：
Pääbo S
中科院分区：
文献类型：
--
作者：
Albert FW;Somel M;Carneiro M;Aximu-Petri A;Halbwax M;Thalmann O;Blanco-Aguiar JA;Plyusnina IZ;Trut L;Villafuerte R;Ferrand N;Kaiser S;Jensen P;Pääbo S
驯化导致了几种动物在形态和行为上的相似变化，这就提出了一个问题，即不同驯化事件之间是否也存在分子水平上的相似性。我们使用mRNA测序分析了三对驯养和野生物种（狗和狼，猪和野猪，驯养和野兔）大脑额叶皮层的全基因组基因表达模式。我们比较了驯化豚鼠和野生远亲（Cavia aperea）之间的表达差异，以及选择对人类的温顺或侵略的两个线的大鼠之间的差异。家犬、家猪、家兔与野生犬、家猪、家兔之间基因表达差异很小（差异表达基因30-75个（不到1%）），而豚鼠和C. aperea差异更大。在不同驯化事件中差异表达的基因之间几乎没有重叠。此外，对所有驯化和野生样本的联合分析只提供了一小部分基因存在的暗示性证据，这些基因在不同的驯化物种中以类似的方式改变了它们的表达。这些共同表达变化中最极端的包括SOX 6和PROM 1（两种大脑发育调节剂）的驯化上调。驯化动物的基因表达与驯服和攻击性大鼠的基因表达几乎没有重叠。然而，大鼠之间表达差异最大的两个基因（DLL 3和DHDH）位于与驯服和攻击相关的基因组区域，这表明它们在影响驯服中发挥作用。总之，大多数驯化动物的大脑基因表达变化是特定的驯化事件，这表明行为驯化性状的致病变体可能同样是不同的。几千年来，人类已经把一系列野生动物物种变成了我们今天所知道的驯养动物。驯化极大地影响了人类的历史和进化。动物的变化更加剧烈。驯养的动物在外表、生理和行为上都不同于它们的野生亲戚。虽然这些差异主要是由基因编码的，但人们对哪些基因促成了这些驯化特征知之甚少。基因表达的变化一直被认为是导致进化中表型变化的原因。因此，在这项工作中，我们比较了狗和狼，猪和野猪，以及家养和野生兔子和豚鼠大脑中的基因表达。对于四个驯化物种中的每一个，我们确定了与野生动物相比可能与行为差异相关的基因表达差异。大多数表达差异是每个驯化事件所独有的，这表明驯化在不同物种中通过不同的遗传途径进行。
Domestication has led to similar changes in morphology and behavior in several animal species, raising the question whether similarities between different domestication events also exist at the molecular level. We used mRNA sequencing to analyze genome-wide gene expression patterns in brain frontal cortex in three pairs of domesticated and wild species (dogs and wolves, pigs and wild boars, and domesticated and wild rabbits). We compared the expression differences with those between domesticated guinea pigs and a distant wild relative (Cavia aperea) as well as between two lines of rats selected for tameness or aggression towards humans. There were few gene expression differences between domesticated and wild dogs, pigs, and rabbits (30–75 genes (less than 1%) of expressed genes were differentially expressed), while guinea pigs and C. aperea differed more strongly. Almost no overlap was found between the genes with differential expression in the different domestication events. In addition, joint analyses of all domesticated and wild samples provided only suggestive evidence for the existence of a small group of genes that changed their expression in a similar fashion in different domesticated species. The most extreme of these shared expression changes include up-regulation in domesticates of SOX6 and PROM1, two modulators of brain development. There was almost no overlap between gene expression in domesticated animals and the tame and aggressive rats. However, two of the genes with the strongest expression differences between the rats (DLL3 and DHDH) were located in a genomic region associated with tameness and aggression, suggesting a role in influencing tameness. In summary, the majority of brain gene expression changes in domesticated animals are specific to the given domestication event, suggesting that the causative variants of behavioral domestication traits may likewise be different. Over the millennia, humans have turned a range of wild animal species into what we today know as domesticated animals. Domestication has greatly influenced human history and evolution. The changes in the animals are even more drastic. Domesticated animals differ from their wild relatives in appearance, physiology, and behavior. Although these differences are mostly genetically encoded, little is known about which genes contribute to these domestication traits. Changes in gene expression have long been proposed to lead to phenotypic changes in evolution. In this work, we therefore compared gene expression in brains of dogs and wolves, pigs and boars, and domesticated and wild rabbits and guinea pigs. For each of the four domesticated species, we identify gene expression differences that could correlate with behavioral differences compared to wild animals. The majority of expression differences are unique to each domestication event, suggesting that domestication has proceeded through different genetic routes in different species.
登录
查看更多内容
影响因子：
14.9
作者：
Hansen KD;Brenner SE;Dudoit S
通讯作者：
Dudoit S
影响因子：
4.5
作者：
Fang M;Larson G;Ribeiro HS;Li N;Andersson L
通讯作者：
Andersson L
影响因子：
9.2
作者：
Chan, Yingguang Frank;Jones, Felicity C.;Tautz, Diethard
通讯作者：
Tautz, Diethard
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
2.5
作者：
Canovas, Angela;Rincon, Gonzalo;Islas-Trejo, Alma;Wickramasinghe, Saumya;Medrano, Juan F.
通讯作者：
Medrano, Juan F.