TNFAIP3 Interacting Protein 3 Is an Activator of Hippo‐YAP Signaling Protecting Against Hepatic Ischemia/Reperfusion Injury
TNFAIP3 Interacting Protein 3 Is an Activator of Hippo‐YAP Signaling Protecting Against Hepatic Ischemia/Reperfusion Injury
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TNFAIP3相互作用蛋白3是Hippo-YAP信号通路的激活物，对肝脏缺血再灌注损伤具有保护作用
DOI：
10.1002/hep.32015
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发表时间：
2021-06
期刊：
影响因子：
13.5
通讯作者：
Junjie Zhou;Manli Hu;Meiling He;Xiaoming Wang;Dating Sun;Yong-Ping Huang;Xu Cheng;Jiajun Fu-Jiajun
中科院分区：
文献类型：
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作者：
Junjie Zhou;Manli Hu;Meiling He;Xiaoming Wang;Dating Sun;Yong-Ping Huang;Xu Cheng;Jiajun Fu-Jiajun
肝脏缺血再灌注(I/R)损伤是肝脏外科手术中常见的临床问题，在早期移植失败和器官排斥反应中占很大比例。确定肝脏I/R损伤的关键调控因子可能为临床改善肝脏手术预后提供潜在的策略。本研究旨在明确肿瘤坏死因子α诱导蛋白3相互作用蛋白3(TNIP3)在肝脏I/R损伤中的作用，并进一步揭示其内在机制。
Hepatic ischemia/reperfusion (I/R) injury, a common clinical problem that occurs during liver surgical procedures, causes a large proportion of early graft failure and organ rejection cases. The identification of key regulators of hepatic I/R injury may provide potential strategies to clinically improve the prognosis of liver surgery. Here, we aimed to identify the role of tumor necrosis factor alpha‐induced protein 3–interacting protein 3 (TNIP3) in hepatic I/R injury and further reveal its immanent mechanisms.