Boron-loaded macromolecules in experimental physiology: tracing by neutron capture radiography.
Boron-loaded macromolecules in experimental physiology: tracing by neutron capture radiography.
复制标题
实验生理学中的载硼大分子：中子俘获射线照相追踪。
DOI：
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发表时间：
1984
影响因子：
3.5
通讯作者：
H. G. Borner
中科院分区：
文献类型：
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作者：
Börje Larsson;Detlef Gabel;H. G. Borner
寻找将硼同位素10B附着到人体中的肿瘤细胞上以治疗恶性疾病的合适方法已经促使了对优化10B在哺乳动物组织中的定位的方法的研究。与各种载体连接的富含硼的化合物已经在实验动物和培养细胞系统中进行了研究。目前的实验条件和结果进行了概述。中子俘获照相法在实验生理学中具有广泛的应用前景。从这个角度提出的技术，并与其他方法相比，通过使用物理或化学原理的大分子标记物的可视化。
The search for suitable methods of attaching the boron isotope 10B to tumour cells in the human body for the treatment of malignant disease has prompted a study of ways of optimising the localisation of 10B in mammalian tissues. Compounds rich in boron, linked to various carriers, have been studied in experimental animals and in systems of cultivated cells. The current experimental prerequisites and results are outlined. The method for 'neutron capture radiography' has significant potential for general application in experimental physiology. The techniques are presented from this viewpoint and compared with other methods for visualisation of macromolecular markers by the use of physical or chemical principles.