Catalytically Asymmetric Pd/Norbornene Catalysis: Enantioselective Synthesis of (+)-Rhazinal, (+)-Rhazinilam, and (+)-Kopsiyunnanine C1-3.
Catalytically Asymmetric Pd/Norbornene Catalysis: Enantioselective Synthesis of (+)-Rhazinal, (+)-Rhazinilam, and (+)-Kopsiyunnanine C1-3.
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DOI：
10.1021/acs.orglett.6b01790
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发表时间：
2016-07
期刊：
影响因子：
5.2
通讯作者：
Kun Zhao;Shibo Xu;Chongqing Pan;X. Sui;Z. Gu
中科院分区：
文献类型：
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作者：
Kun Zhao;Shibo Xu;Chongqing Pan;X. Sui;Z. Gu
本文报道了钯/环己烯催化的不对称催化反应，其中α-芳基四氢喹啉衍生的亚磷酰胺L15是最佳配体。利用这一转化，实现了（+）-嗪醛、（+）-嗪尼兰和（+）-云南山茱萸碱C1、C2和C3的简洁、统一的对映选择性合成。
A catalytically asymmetric palladium/norbornene-catalyzed reaction is reported, where α-aryl tetrahydroquinoline derived phosphoramidite L15 is found to be the optimum ligand. Taking advantage of this transformation, the concise and unified enantioselective syntheses of (+)-rhazinal, (+)-rhazinilam, and (+)-kopsiyunnanine C1, C2, and C3 are realized.