Supportive text messaging for depression and comorbid alcohol use disorder: single-blind randomised trial
Supportive text messaging for depression and comorbid alcohol use disorder: single-blind randomised trial
复制标题
DOI：
10.1016/j.jad.2012.02.040
复制
发表时间：
2012-12-10
影响因子：
6.6
通讯作者：
Farren, Conor K.
中科院分区：
文献类型：
--
作者：
Agyapong, Vincent I. O.;Ahern, Sinead;Farren, Conor K.
背景资料：移动的手机短信技术有可能改善抑郁症和共病酒精使用障碍（AUD）患者的结局。目的：进行一项随机评分者盲法试验，探讨支持性短信对抑郁症和共病AUD患者的情绪和戒酒结局的影响。方法：参与者（n=54），DSM IV诊断为单相抑郁症和AUD，完成住院双诊断治疗计划，随机接受每日两次支持性短信（n=26）或每两周一次的感谢短信（n=28），持续三个月。主要结果指标是贝克抑郁量表（BDI-II）评分和三个月时的累积禁欲持续时间（CAD）。试验注册：结果：干预组和对照组之间的三个月BDI-II评分存在统计学显著差异;在调整基线评分后，分别为8.5（SD=8.0）vs. 16.7（SD=10.3），F（1，49）=9.54，p=0.003，eta（2）（p）=0.17。BDI-II评分变化的平均差异为-7.9（95% CI -13.06至-2.76，Cohen's d=0.85）。短信组的CAD有高于对照组的趋势：88.3（SD=6.2）vs. 79.3（SD=24.1），t=1.78，df=48，p= 0.08。局限性：该研究的局限性包括样本量小，评估者盲法丧失的可能性以及缺乏长期随访以确定干预的长期效果。支持性短信有可能改善抑郁症和酒精依赖综合征共病患者的预后。(C)2012年爱思唯尔B。V.保留所有权利。
Background: Mobile phone text message technology has the potential to improve outcomes for patients with depression and co-morbid Alcohol Use Disorder (AUD).Aims: To perform a randomised rater-blinded trial to explore the effects of supportive text messages on mood and abstinence outcomes for patients with depression and co-morbid AUD.Methods: Participants (n=54) with a DSM IV diagnosis of unipolar depression and AUD who completed an in-patient dual diagnosis treatment programme were randomised to receive twice daily supportive text messages (n=26) or a fortnightly thank you text message (n=28) for three months. Primary outcome measures were Beck's Depression Inventory (BDI-II) scores and Cumulative Abstinence Duration (CAD) in days at three months. Trial registration: NCT0137868.Results: There was a statistically significant difference in three month BDI-II scores between the intervention and control groups; 8.5 (SD=8.0) vs. 16.7 (SD=10.3) respectively after adjusting for the baseline scores, F (1, 49)=9.54, p=0.003, eta(2)(p)=0.17. The mean difference in change BDI-II scores was -7.9 (95% CI -13.06 to -2.76, Cohen's d=0.85). There was a trend for a greater CAD in the text message group than the control group: 88.3 (SD=6.2) vs. 79.3 (SD=24.1), t=1.78, df=48, p=0.08.Limitations: Limitations of the study include the small sample size, the potential for loss of rater blinding and the lack of long term follow-up to determine the longer term effects of the intervention.Conclusion: Supportive text messages have the potential to improve outcomes for patients with comorbid depression and alcohol dependency syndrome. (C) 2012 Elsevier B. V. All rights reserved.