Vaccination and Therapeutics: Responding to the Changing Epidemiology of Yellow Fever
Vaccination and Therapeutics: Responding to the Changing Epidemiology of Yellow Fever
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DOI：
10.1007/s40506-020-00232-7
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发表时间：
2020-07-10
影响因子：
2
通讯作者：
de Alwis, Ruklanthi
中科院分区：
文献类型：
--
作者：
Bifani, Amanda Makha;Ong, Eugenia Z.;de Alwis, Ruklanthi
回顾目的 十九世纪初，黄热病（YF）被认为是最危险的传染病，病死率很高。随后，大规模疫苗接种运动加上广泛消除黄热病蚊媒，显着减少了黄热病病例，并减少了非洲和南美洲热带和亚热带森林地区的疫情爆发。最新发现 然而，最近（2016 年）在安哥拉、刚果民主共和国 (DRC) 和巴西东南部（此前被划定为低风险地区）爆发的大规模疫情凸显了流行病学迅速变化的可能性以及黄热病病毒 (YFV) 可能重新出现的可能性。此外，YFV 首次进入亚洲，凸显了人们对 YFV 成为全球威胁的潜在担忧。在这篇综述中，我们描述了黄热病疫情不断变化的流行病学，并强调使用公共卫生政策、治疗方法和疫苗接种作为帮助消除未来黄热病疫情的工具。
Purpose of Review At the turn of the nineteenth century, yellow fever (YF) was considered the most dangerous infectious disease with high case fatality. Subsequent, mass vaccination campaigns coupled with widespread elimination of the YF mosquito vector significantly decreased YF cases and reduced outbreaks to the tropical and subtropical forested regions of Africa and South America. Recent Findings However, recent (2016) large outbreaks in Angola, Democratic Republic of Congo (DRC), and South-Eastern Brazil, where previously had been demarcated as low-risk regions, have highlighted the possibility of a rapidly changing epidemiology and the potential re-emergence of yellow fever virus (YFV). Furthermore, the first-ever importation of YFV into Asia has highlighted the potential fear of YFV emerging as a global threat. In this review, we describe the changing epidemiology of YF outbreaks and highlight the use of public health policies, therapeutics, and vaccination as tools to help eliminate future YFV outbreaks.