Inhibition of macrophage migration inhibitory factor reduces endometriotic implant size in mice with experimentally induced disease
Inhibition of macrophage migration inhibitory factor reduces endometriotic implant size in mice with experimentally induced disease
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DOI：
10.5301/je.2011.8910
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发表时间：
2011-07-01
影响因子：
0.5
通讯作者：
Al-Abed, Yousef
中科院分区：
文献类型：
--
作者：
Nothnick, Warren B.;Colvin, Arlene;Al-Abed, Yousef
Aim: Macrophage migration inhibitory factor (MIF) is a cytokine whose expression is elevated in endo-metriotic tissue from women with the disease but the functional role of this factor in the pathogenesis of the disease is uncertain. The objective of the current study was to examine the role of MIF in the pathogenesis of endometriosis.Method: Experimental endometriosis was induced in mice and the ability of the MIF antagonist, ISO-1, to reduce endometriotic implant size was assessed.Results: Administration of ISO-1 resulted in a significant reduction in implant size and vascularity (as assessed by Flk1 mRNA expression) which was not associated with an alteration in the reproductive cycle.Conclusion: These data suggest that inhibition of MIF activity is associated with a significant reduction in endometriotic implant size and leads us to speculate that a similar approach of targeting MIF may prove useful in treating endometriosis in humans.
