Isolated heart transplant and combined heart-liver transplant in adult congenital heart disease patients: Insights from the united network of organ sharing
Isolated heart transplant and combined heart-liver transplant in adult congenital heart disease patients: Insights from the united network of organ sharing
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DOI：
10.1016/j.ijcard.2016.11.121
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发表时间：
2017-02-01
影响因子：
3.5
通讯作者：
Daniels, Curt
中科院分区：
文献类型：
--
作者：
Bradley, Elisa A.;Pinyoluksana, Krong-on;Daniels, Curt
背景/方法：患有严重先天性心脏病 (CHD) 的老年患者面临着许多挑战：心力衰竭、心律失常，以及 Fontan 患者的肝病。我们的目标是确定美国成年 CHD 患者联合心肝移植 (CHLT) 和孤立原位心脏移植 (OHT) 的结果。从 2014 年开始，对美国联合器官共享网络 (UNOS) 胸部和肝脏数据库进行了心脏和 CHD 诊断的查询。结果：在 CHLT 中，CHD 占候补患者的 22%（非 CHD n=262 与 CHD n=58），占移植患者的 20%（非 CHD n=137 与 CHD n=27）。非CHD组和CHD组的肝功能检查相似，CHD组和非CHD组的生存率没有差异（HR 0.93，CI：0.36-2.38，p < 0.48）。在孤立的 OHT 中，CHD 患者占所列患者（非 CHD n=74,080 对比 CHD n=1599）和移植患者（非 CHD n=48,985 对比 CHD n=967）的 2%，并且早期（
Background/methods: The aging patient with severe congenital heart disease (CHD) faces many challenges: heart failure, arrhythmia, and in the Fontan patient, liver disease. Our goal was to define combined heart liver transplant (CHLT) and isolated orthotopic heart transplant (OHT) outcomes in U.S. adult CHD patients. The U.S. United Network for Organ Sharing (UNOS) thoracic and liver databases were queried for cardiac and CHD diagnoses, from inception-2014.Results: In CHLT, CHD made up 22% of waitlist patients (non-CHD n=262 vs. CHD n=58), and 20% of transplanted patients (non-CHD n=137 vs. CHD n=27). Liver function tests in the non-CHD and CHD groups were similar and there was no difference in CHD and non-CHD survival (HR 0.93, CI: 0.36-2.38, p 0.48). In isolated OHT, CHD patients comprised 2% of those listed (non-CHD n=74,080 vs. CHD n=1599) and transplanted (non-CHD n=48,985 vs. CHD n=967) and had higher early (