Viral vectors for vaccine applications.
Viral vectors for vaccine applications.
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DOI：
10.7774/cevr.2013.2.2.97
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发表时间：
2013-07
影响因子：
2.7
通讯作者：
Chang J
中科院分区：
文献类型：
--
作者：
Choi Y;Chang J
传统的灭活或减毒活疫苗免疫方法在减少和控制传染病爆发方面取得了令人印象深刻的成功。然而，许多病原体仍然不太适合处理传统的疫苗策略，需要更合适的疫苗策略。最近的发现，导致病毒分子生物学和遗传学的理解增加，使病毒作为疫苗平台和作为潜在的抗癌剂的使用。由于它们能够有效地诱导体液和细胞介导的免疫应答，病毒载体被认为是递送疫苗抗原以及特异性靶向和杀死肿瘤细胞的传统平台的有吸引力的替代方案。由于潜在的靶点范围从癌症到大量的传染病，成功应用病毒载体预防和治疗人类疾病所带来的好处可能是巨大的。
Traditional approach of inactivated or live-attenuated vaccine immunization has resulted in impressive success in the reduction and control of infectious disease outbreaks. However, many pathogens remain less amenable to deal with the traditional vaccine strategies, and more appropriate vaccine strategy is in need. Recent discoveries that led to increased understanding of viral molecular biology and genetics has rendered the used of viruses as vaccine platforms and as potential anti-cancer agents. Due to their ability to effectively induce both humoral and cell-mediated immune responses, viral vectors are deemed as an attractive alternative to the traditional platforms to deliver vaccine antigens as well as to specifically target and kill tumor cells. With potential targets ranging from cancers to a vast number of infectious diseases, the benefits resulting from successful application of viral vectors to prevent and treat human diseases can be immense.