THE LATE SOMATOSENSORY EVOKED-POTENTIAL IN PREMATURE AND TERM INFANTS .1. PRINCIPAL COMPONENT TOPOGRAPHY
THE LATE SOMATOSENSORY EVOKED-POTENTIAL IN PREMATURE AND TERM INFANTS .1. PRINCIPAL COMPONENT TOPOGRAPHY
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DOI：
10.1016/0168-5597(92)90066-k
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发表时间：
1992-01-01
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影响因子：
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通讯作者：
KARNISKI, W
中科院分区：
文献类型：
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作者：
KARNISKI, W
对早产儿皮质体感诱发电位的地形图分布知之甚少。应用主成分分析(PCA)方法对53例31~40周龄婴儿右侧正中神经刺激产生的16个电极的相对长扫描(刺激后483毫秒)产生的波形进行分析，按2周递增分为5组。各因素得分在不同受试者中平均，并以地形图的形式显示。4个因素解释了5组中每组71%~76%的方差，从每组独立进行的主成分分析中提取的因素具有明显的一致性。第一个因子(N1/P1)有一个左后极小值和一个左额中极大值，可能代表位于中央后回的切线偶极子。第二个因素(N2)的特征是一致的左中央最小值，最大值有系统性的发展变化，似乎暗示其神经生成器随着婴儿的成熟而在方向上发生变化。第三个因素(N3)解释了最大的差异，似乎代表了同侧皮质活动的第一个证据。最后，非常晚的第四个因素只出现在更成熟的群体中。具有不确定的本地化。这4个因素的因子得分的地形图似乎解释了早产儿和足月儿SEP的独立产生因素。
Very little is known about the topographic distribution of the cortical somatosensory evoked potential in premature infants. Principal component analysis (PCA) was applied to the wave forms generated from right median nerve stimuli over a relatively long sweep (483 msec post stimulus) at 16 electrodes in 53 infants with postconceptual ages from 31 to 40 weeks, subdivided into 5 groups by 2 week increments. Factor scores were averaged across subjects, within groups and displayed as topographical maps. Four factors accounted for 71-76% of the variance in each of the 5 groups and the factors extracted from the PCA performed independently in each group were markedly consistent. The first factor (N1/P1) had a left posterior minimum and a left frontal-central maximum and probably represents a tangential dipole located in the post-central gyrus. The second factor (N2) was characterized by a consistent left central minimum with a systematic developmental change in the maximum that seemed to imply that its neural generator was changing in orientation as the infants matured. A third factor (N3) accounted for the most variance and appeared to represent the first evidence of activity in the ipsilateral cortex. Finally, a very late fourth factor appeared only in the more mature groups. with uncertain localization. The topographic maps of the factor scores for these 4 factors appear to account for independent generators in the SEP of the premature and term infant.