Applications of atmospheric pressure plasma in microbial inactivation and cancer therapy: a brief review
Applications of atmospheric pressure plasma in microbial inactivation and cancer therapy: a brief review
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大气压等离子体在微生物灭活和癌症治疗中的应用：简要回顾
DOI：
10.1088/2058-6272/ab9ddd
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发表时间：
2020
影响因子：
1.7
通讯作者：
Cheng Cheng
中科院分区：
文献类型：
--
作者：
Xu Zimu;Lan Yan;Ma Jie;Shen Jie;Han Wei;Hu Shuheng;Ye Chaobing;Xi Wenhao;Zhang Yudi;Yang Chunjun;Zhao Xiao;Cheng Cheng
常压冷等离子体具有粒子活性高、无热损伤、效率高以及与人体组织直接友好接触等优点，被认为在生物医学应用中具有巨大潜力。因此，“血浆医学”作为一门新的交叉学科是近二十年来发展起来的。本文首先简要介绍了适合生物医学应用的典型等离子体源的发展，并对不同放电形式的等离子体源进行了简单的比较、评估和总结。随后，介绍了关键气态反应粒子（例如 OH 和 O）及其时空分布的测量。同时总结了等离子体诱导的水反应物种的产生和变化规律以及相关的临界宏观参数。最后介绍了近十年来等离子体驱动微生物灭活和等离子体诱导癌细胞凋亡机制的相关研究。此外，还讨论了血浆医学领域急需解决的一些科学问题。该综述将为今后的相关研究提供有益的指导。
Atmospheric pressure cold plasma, with advantages such as high particle activity, no thermal damage, high efficiency and direct and friendly contact with human tissues, is considered to have great potential in biomedical applications. Therefore,'plasma medicine'as a new interdiscipline has been developed in the past two decades. This review first briefly describes the development of typical plasma sources suitable for biomedical applications, and those with different discharge forms are simply compared, evaluated and summarized. Subsequently, measurement of the crucial gaseous reactive particles (eg OH and O) and their spatio-temporal distributions are introduced. Meanwhile, the generation and variation rules and the related critical macroscopic parameters of the plasma-induced aqueous reactive species are summarized. Finally, related studies in the last ten years on the mechanisms of the plasma-driven microbial inactivation and plasma-induced apoptosis of cancer cells are introduced. Moreover, some scientific problems that need to be urgently solved in the field of plasma medicine are also discussed. This review will provide useful guidance for future related research.